Rosalind Franklin's research was central to the discovery of the double-helix structure of DNA. She never received the credit she was due during her lifetime.
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Rosalind Franklin's research was central to the discovery of the double-helix structure of DNA. She never received the credit she was due during her lifetime.
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Rosalind Franklin was a chemist doing x-ray crystallography on DNA (deoxyribonucleic acid) in Maurice Wilkins' laboratory at King's College, London. Concurrently, James Watson and Francis Crick were trying to puzzle out DNA's molecular structure in the Cavendish Laboratory at Cambridge. Technically the two institutions were not competitors, because the English scientific establishment had "ceded" the DNA problem to King's. The world knows that Watson and Crick were first to publish the correct structure of the substance which encodes and controls every detail of the configuration, development, maintenance and reproduction of living things.
Watson and Crick were the kind of bad boys we generally admire. From positions very low on the Cavendish totem pole, they tunneled under, around and through the decorous conventions of incremental science to snatch a Nobel-caliber breakthrough from the very hands of the people who were supposed (eventually) to produce it. They even had a plausible excuse for ethical shortcuts, because the American superstar-chemist Linus Pauling, unconstrained by British decorum, was known to be working on the DNA structure.
In 1968, Watson published "The Double Helix", an entertaining and irreverent personal account of the triumph he and Crick had achieved in 1953. On the positive side, the book gave many people (including myself) their first look at the fascinating scientific and human details of a brilliant achievement in the relatively new field of molecular biology. On the negative side, Watson's version of the story did not please everyone who had prior knowledge of the people and events involved. Among the least pleased, to put it mildly, were the family and friends of Rosalind Franklin (Ms. Franklin herself did not live to see the cruelly caricatured "Rosy" that Watson sketched for his largely naive and trusting audience.)
One of the friends, Anne Sayre, took on the task of providing a comprehensive portrait of Franklin, interwoven with a retelling of the DNA story centered on the tragic consequences flowing from the simple inability of two intelligent people (Franklin and Wilkins) to get along. But the book is much more than a psychological study. Sayre documents some unambiguous facts that establish what Franklin knew about DNA and when she knew it. Also revealed are the instances in which her work was used without her knowledge and, even more unfortunately, the degree to which misunderstanding of Franklin's conclusions about the B-form of DNA slowed everyone's progress and robbed her of due credit.
I found Sayre to be unfailingly perceptive and balanced while following a course of strong, even indignant, advocacy. This is no mean feat, and follows in part from her extensive interviews with all the principals, as well as fruitful discussions with her scientist husband. I highly recommend the book to anyone interested in gaining perspective on the DNA story, and on science itself.
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