I have reviewed this book fairly extensively on my blog. So, for those interested in a more detailed discussion of the scientific issues dealt with in the book than I can do on Amazon. EDIT: The link is provided in the comments, as links can't appear in the main text.
In this book Gauger, Axe and Luskin purport to deal with broad issues of human origins in a scientific context - our common descent within the primates, the ability of natural selection to produce novel function, the hominin fossil records and ancestral population sizes (whether we could or could not have gone through a population bottleneck of two people for a literal Adam and Eve. They spectacularly fail to manage what they set out to achieve, which is to provide a scientific justification of Christian principles.
I realise there will be people who will argue that because this is an Intelligent Design book, I am wrong to bring up Christianity, because it is a purportedly secular movement. However, the introduction and four of the five chapters in this book *explicitly* set out their arguments in this context, and the final chapter talks about a literal Adam and Eve. This is an overtly Christian book, and while there is nothing wrong with that, it is also clear that this means that the authors are presenting a one-sided case about human origins.
Even a one-sided case would be fine - provided the authors deal with the scientific arguments at hand properly. However, the book achieves no such thing. Chapter One provides a broad overview of the book. In Chapter Two (Douglas Axe) sets about to disprove that Darwinian evolution can produce novel proteins. However, the argument is based on a flawed concept of evolution - that if we can't evolve one contemporary protein into another, then evolutionary novelty cannot happen by mutation and selection. The problem with this argument is that evolution does not occur with targets in mind, and transitions between one chosen protein and another are not expected. It is easy to imagine lots of proteins that could evolve but haven't. That one particular, preordained change is unlikely to happen is not evidence against evolution, and does not address the enormous existing subdiscipline that deals with evolutionary constraints.
In Chapter 3, lawyer and MSc (earth sciences) Casey Luskin argues against all of the world's expert palaeoanthropologists that there are in fact massive, unbridgeable gaps in the fossil record that disprove common descent of humans and chimpanzees. He argues that most of the record is primarily very much dominated by arboreal apes, and then there is a sudden transition into terrestrial humans. Even ignoring his unfair treatment of Homo habilis, Luskin is wrong to suggest that modern humans appear significantly unchanged as Homo erectus, and that we are effectively no different from erectus. In fact, erectus shows a doubling of cranial capacity over its evolutionary history, which means that early erectus is very unlikely to have been "human" in the way Luskin wants - a creature created in the image of God, with capacity for thought, and art and so forth. This also sets up a later failure by Ann Gauger in the last chapter.
Chapter 4 is also authored by Luskin, however in this chapter he challenges the concept of junk DNA and personally attacks Christian geneticist Francis Collins. The junk DNA argument he presents is massively ignorant of the literature, and is one long strawman. He argues that evolutionary biologists used to think that all non-coding DNA was junk but they were all wrong and now we know that all DNA is functional. Every part of this statement is wrong. The concept of junk DNA was established through population genetics by Ohno in 1972. Ohno argued that we could only have a maximum of 30,000 functional genes and the rest of the genome (his estimate was 90%) was not under purifying selection. The reason is that the more function in the genome, the more room for things to go wrong with mutation. Because we all have mutations that arose in us if they all affected functional parts of the genome, we would evolve to extinction. This is because most random mutations to functional parts of the genome make them worse, not better. Luskin is completely ignorant of this, and makes no argument as to how the whole genome could be functional. Even though we have known about functional non-coding DNA for longer than we have known about junk DNA, he still claims that scientists thought all non-coding DNA was junk. He lists a bunch of functions in non-coding DNA that nobody disputes, but these functions simply do not apply to the 90% of the genome that lacks any known function (yes, Ohno was about right 40 years ago!). While we continue to find new functional sequences in the genome and while this is cool and exciting, we just have to remember that most of these finds account for tiny fragments of our genome, and all of them added up over decades still add up to less than a couple percent of the genome, and that any argument against junk DNA needs to explain how Ohno was wrong. There are also other issues here like pervasive transcription and chromosomal fusion, but like the rest of the chapter, Luskin only provides one side of complex issues and pretends to have a scientific consensus that literally does not exist. It is either dishonest or ignorant.
In the last chapter, Ann Gauger makes an argument for a literal Adam and Eve. However, she too ignores the best reasons that we know the human population never bottlenecked to only two individuals, instead arguing about one single paper from the 1990s. Even this argument is badly flawed, because it requires Adam and Eve to be at least 4 million years in the past. However, Luskin argued in Chapter 3 that `humanness' has only existed since Homo erectus - about 1.8 million years in the past. Like I said, the possibility of Adam and Eve at 4 million years ago is only based on one point, and the bulk of scientific evidence shows that the hominin lineage has never experienced a bottleneck of this type.
Gauger then makes the only original claim in favour of intelligent design, in the last couple pages of the book. However, like the rest of the book the argument contains no positive evidence for this position, and is only predicated on doubt about naturalistic evolution.
The book will still probably be read by many people seeking to disprove evolution. I urge those people to consider why all of the scientists who work in these fields collectively come to different conclusions than do the authors of this book. It is not because of an atheist conspiracy, as many of those scientists - including Francis Collins and Francisco Ayala who are singled out in this book - are themselves Christians. They accommodate their beliefs with an uncompromised view of the science. This is because they have engaged openly with the evidence of their discipline and concluded that evolutionary principles best explain human origins. If this book offers any solace to those seeking evidence against evolution for their faith, the solace should be as incomplete as the arguments made in the book.