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Sequence - Evolution - Function: Computational Approaches in Comparative Genomics
 
 
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Sequence - Evolution - Function: Computational Approaches in Comparative Genomics [Hardcover]

Eugene V. Koonin (Author), Michael Y. Galperin (Author)

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Book Description

October 1, 2002
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

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Inside This Book (learn more)
First Sentence:
In the early spring of 1980, one of the authors of this book (EVK) was an excited listener to a seminar presented in Moscow State University, the authors' alma mater, by a well-known virologist, a scientist of rare creativity, and later a good friend, Anatoly Altstein. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
narrow phyletic distribution, gene displacement, phyletic patterns, phosphoglycerate mutase activity, phosphonopyruvate decarboxylase, protein universe, goose lysozyme, low sequence conservation, minimal gene set, domain accretion, archaeal genomes, uridylate kinase, genome annotation, anthranilate phosphoribosyltransferase, enzyme recruitment, multidomain architecture, other archaea, spurious hits, domain hits, bacteria encode, bacterial homologs, gluconate kinase, taxonomic breakdown, compare your conclusions, structural neighbors
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Entrez Proteins, Sanger Centre, Rosetta Stone, Cold Spring Harbor Laboratory, Genome Research, Human Genome Project, Margaret Dayhoff, Program Author, Research Institute, San Diego, Text Word, The Origin of Species, Washington University, Charles Darwin, David Eisenberg, Kenta Nakai, Nucleic Acids Research, Oak Ridge, Stephen Altschul, Steven Brenner, Cambridge University Press, Comment Ref, Institute Pasteur, Kazusa Institute, Last Universal Common Ancestor
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