A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
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Book Description
Editorial Reviews
Review
From the reviews: "This is a compilation of reviews regarding various aspects of serotonin receptor structure and function. … As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. … Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material. … is a good, comprehensive set of reviews. … overall, it is a valuable book." (Eugene A Davidson, Doody’s Review Service, February, 2007)
From the Back Cover
The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction. Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.
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First Sentence:
The G protein-coupled serotonin (5-hydroxytryptamine; 5-HT) receptors are typical group A rhodopsin-like G protein-coupled receptors (GPCRs) in that they are predicted to possess seven transmembrane spanning helices, three intracellular and three extracellular loops, an extracellular amino-terminus, and an intracellular carboxy-terminus. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
stimulus trafficking, antidepressant phenotype, anxiogenic phenotype, receptor silences constitutive activity, anxiolytic phenotype, helix irregularity, novel rat serotonin, receptor sequence encodes, marked constitutive activity, traditional receptor theory, cardiopulmonary side effects, anterodorsal thalamus, constitutive receptor activity, rat dorsal raphe neurons, signaling linkages, simple tryptamines, receptor pseudogene, novel serotonin receptor, human serotonin receptor, receptor splice variants, edited isoforms, decreased immobility, serotonergic ligands, serotonin receptor ligands, tricyclic psychotropic drugs Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, Mol Pharmacol, Biol Chem, Proc Natl Acad Sci, Pharmacol Exp Ther, Med Chem, Neurosci Lett, Comp Neurol, Trends Pharmacol Sci, Naunyn Schmiedebergs Arch Pharmacol, Biol Psychiatry, Med Genet, Biochem Biophys Res Commun, Human Therapeutics Edited, Humana Press Inc, Key Words, Naunyn-Schmiedebergs Arch Pharmacol, Serotonin System Gene Knockouts, Mol Psychiatry, Pharmacol Biochem Behav, Soc Neurosci Abstr, Life Sci, Neurol Disord, Curr Drug Targets, Pharmacol Ther New!
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The G protein-coupled serotonin (5-hydroxytryptamine; 5-HT) receptors are typical group A rhodopsin-like G protein-coupled receptors (GPCRs) in that they are predicted to possess seven transmembrane spanning helices, three intracellular and three extracellular loops, an extracellular amino-terminus, and an intracellular carboxy-terminus. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
stimulus trafficking, antidepressant phenotype, anxiogenic phenotype, receptor silences constitutive activity, anxiolytic phenotype, helix irregularity, novel rat serotonin, receptor sequence encodes, marked constitutive activity, traditional receptor theory, cardiopulmonary side effects, anterodorsal thalamus, constitutive receptor activity, rat dorsal raphe neurons, signaling linkages, simple tryptamines, receptor pseudogene, novel serotonin receptor, human serotonin receptor, receptor splice variants, edited isoforms, decreased immobility, serotonergic ligands, serotonin receptor ligands, tricyclic psychotropic drugs Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, Mol Pharmacol, Biol Chem, Proc Natl Acad Sci, Pharmacol Exp Ther, Med Chem, Neurosci Lett, Comp Neurol, Trends Pharmacol Sci, Naunyn Schmiedebergs Arch Pharmacol, Biol Psychiatry, Med Genet, Biochem Biophys Res Commun, Human Therapeutics Edited, Humana Press Inc, Key Words, Naunyn-Schmiedebergs Arch Pharmacol, Serotonin System Gene Knockouts, Mol Psychiatry, Pharmacol Biochem Behav, Soc Neurosci Abstr, Life Sci, Neurol Disord, Curr Drug Targets, Pharmacol Ther New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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