This book is freaking awesome! I could really identify with Sabrina -- the main character in the I Sin Every Number half of the novel -- and the problems she was having.
Yes, to apreciate this book you should probably have a little experience with experimental fiction (Burroughs, Barthelme, Acker) before going in. There are chapters here that were obviously generated by computer programs, but Christ you don't have to read each word of them before going on to the next "straight" portion of the novel; just let your eyes skim and wander through the text and get the feel of the semi-poetic nature of the machine-based prose that Sabrina was seeing on her computer screen. I believe the author was attempting to immerse the reader in Sabrina's world so they could see the scary messages she was getting. It's a cool idea! If you tried to read every word of the experimental stuff, of course it would be tedious, but when it gets too much just continue on to the next "story" chapter.
This novel is avant-garde, adventurous writing at its best. The characters are interesting and well-developed, and there are even quite a few humorous incidents in the book. Don't be a square. Be bold and pick up this novel and maybe a few mighty forces will come to your aid while you're reading it.
Also be sure to check out the 'Note From the Author' at the very end! I've never seen anything like it before.