Best Books of the Month Shop Costumes Learn more nav_sap_plcc_6M_fly_beacon Janet Jackson All-New Amazon Fire TV Grocery Amazon Gift Card Offer gdwf gdwf gdwf  Amazon Echo Starting at $49.99 Kindle Voyage Nintendo Digital Games Shop Now Halloween
& FREE Shipping on orders over $35. Details
Only 1 left in stock.
Ships from and sold by Gift-wrap available.
Side Effects has been added to your Cart
Used: Very Good | Details
Condition: Used: Very Good
Comment: Cut out. The case is in Very Good Condition. The DVD(s) is/are in very good shape.
Other Sellers on Amazon
Lowest price: Used - Like New
+ $3.99 shipping
Sold by: newtownvideos
Seller Rating: 4.9 out of 5 stars (360999)
Add to Cart
Buy New
+ $3.99 shipping
Buy New
+ $3.99 shipping
Have one to sell? Sell on Amazon

Side Effects

77 customer reviews

Additional DVD options Edition Discs
Amazon Price
New from Used from
(May 16, 2006)
"Please retry"
$8.65 $0.74
Watch Instantly with Rent Buy

Unlimited Streaming with Amazon Prime
Unlimited Streaming with Amazon Prime Start your 30-day free trial to stream thousands of movies & TV shows included with Prime. Start your free trial
$24.99 & FREE Shipping on orders over $35. Details Only 1 left in stock. Ships from and sold by Gift-wrap available.

Frequently Bought Together

  • Side Effects
  • +
  • One For the Money
  • +
  • Killers
Total price: $34.93
Buy the selected items together

Editorial Reviews

Product Description

Karly Hert (Katherine Heigl) has spent the last ten years selling drugs... legally, that is. She’s works for one of corporate America’s darlings, the pharmaceutical industry. Karly has it all – a big salary, a company car, a closet full of hot business suits and a growing pit in her stomach... Everything changes when she meets sexy Zach Danner (Lucian McAfee), a down-to-earth guy. Sparks fly! As their relationship heats up, he encourages Karly to walk her talk and leave her empty job. Karly devises a plan to get out.

But somehow leaving is never quite as easy as it seems... SIDE EFFECTS is based on the writer/director's decade working for the pharmaceutical industry and stars Grey’s Anatomy’s hottest intern Katherine Heigl.

It’s the perfect prescription for a new comedy!

A well-intentioned film about a young pharmaceutical rep who is torn between earning a good living and living a good life, Side Effects tells the story of Karly Hert, portrayed by Katherine Heigl (Grey's Anatomy, Roswell), who also executive produced the project. Karly works for a company whose motto is "To protect and prolong life." But what they really mean is prolong their own) lives by making as much money as possible. Based on writer-director Kathleen Slattery-Moschkau's previous career as a legal pill pusher, Side Effects is a comedy with an agenda. Its goal is to educate viewers about the dangers of an uneducated sales force telling doctors which drugs to prescribe--regardless of the side effects. While Slattery-Moschkau is heavy handed in her delineation of who is good (the patients) and evil (the drug reps), her semi-autobiographical Karly is relatable. When we meet her, Karly has no patience with her pod-like boss. When her employer rhetorically asks, "How do you think I ended up in management?" Karly zings back, "There are rumors." But as she herself moves up in the company and earns expensive perks, Karly is seduced. Heigl gives an earnest, likable performance, especially during scenes with Lucian McAfee, who plays her boyfriend Zach. While her Norma Rae moment at the end of the film doesn't ring quite true, it gives the movie a fitting ending that ties together all the loose ends. --Jae-Ha Kim

See all Editorial Reviews

Special Features

  • Director commentary
  • Bonus documentary
  • Behind the scenes footage
  • Trailer

Product Details

  • Actors: Katherine Heigl, Lucian McAfee
  • Format: Multiple Formats, Closed-captioned, Color, Full length, Letterboxed, Subtitled, Surround Sound, Widescreen, NTSC
  • Language: English (Dolby Digital 2.0 Stereo), English (Dolby Digital 5.1)
  • Subtitles: English, Spanish, French
  • Region: All Regions
  • Aspect Ratio: 2.35:1
  • Number of discs: 1
  • Rated: R (Restricted)
  • Studio: Hummingbird Pictures
  • DVD Release Date: May 16, 2006
  • Run Time: 90 minutes
  • Average Customer Review: 3.2 out of 5 stars  See all reviews (77 customer reviews)
  • ASIN: B000EOTSA0
  • Amazon Best Sellers Rank: #198,726 in Movies & TV (See Top 100 in Movies & TV)
  • Learn more about "Side Effects" on IMDb

Customer Reviews

Most Helpful Customer Reviews

Format: DVD
At the very beginning of "Side Effects," our heroine, Karly Hert (Katherine Heigl), tells us that she sells drugs for a living, quickly adding that she does it legally. Karly is not a drug pusher; she is a sales rep for a pharmaceutical company. Writer/director/producer Kathleen Slatery-Moschkau worked several years in just such a job, so her objective here is to air the industry's dirty laundry and possibly convince you that drug pushers might not be that bad in comparison for the simple reason that the drug companies do not take as much of your money.

Katy is hired by the company, not because she knows anything about pharmaceuticals, but because she is a babe. However, Katy is not really comfortable in a corporate world where making money is the bottom line and her boss prefers that she wear panty hose is she is gong to wear a skirt. On the other hand, when they hired her they gave Katy a company car and that is nothing to sneeze at. Then Katy meets Zach Danner (Lucian McAfee), who is the antithesis of the world in which she lives. Zach's goal is build his own house and this ideal makes up for the fact he does not look like your typical leading man in a movie. Still, Katy is committed to their future together and circles the date on the calendar when she will quit her job so they can go built their home in the woods.

At that point "Side Effects" takes an interesting satirical turn because Katy decides that instead of following the company's scripts for selling durgs she is going to tell doctors the truth (to wit, their product is not any better than comparable products by their competitors, just more expensive).
Read more ›
2 Comments Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
15 of 18 people found the following review helpful By Matt Conner on June 26, 2006
Format: DVD Verified Purchase
This movie has a lot of strikes against it - the different "locations" are frequently the same room with furniture rearranged. Narrative devices like text on screen or interlude interviews are picked up and abandoned at random. Subplots (in particular, those involving Karly's best friend and the rest of her family) are never resolved, and the dialogue is frequently clunky exposition of company rhetoric. Many of the supporting actors are obviously not in the same league as the main players, and it's not hard to predict the plot points of the film.

But the movie has heart and a winning lead actress in Katherine Heigl, and this movie has become one of my guilty pleasures. As a medical professional, I have heard all of the arguments for and against drug reps as depicted in this film, but the scenes where Karly shows how hard it is to do her job were particularly convicting. Corporate ethics aside, these are personal issues, and most of these people are just trying to pay the bills. The movie really humanizes the industry reps, even if the characters themselves aren't exactly three-dimensional.

And yes, Katherine Heigl takes her top off. Twice. I would consider it exploitative except that she executive produced this movie, and in that case, if you've got it, flaunt it. The brief nudity does fit logically into the scenes.

In the end, I recommend watching this movie with as light a heart as possible (and a little vodka, if you've got it). It's not revolutionary, but it raises good discussion points, and it will give you a fix until you can see Katherine Heigl on the far superior Grey's Anatomy.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
13 of 16 people found the following review helpful By Michael R. on April 3, 2006
Format: DVD
I enjoyed this film for two reasons:

First, Katherine Heigl. Being a huge fan of Grey's Anatomy and of Katherine Heigl I had a hunch I would enjoy this movie, but her performance was even better than I expected. This is a bigger film role than normal for her, but she tackles it with ease and shows much more of her range than she does on Grey's. She gets the driven, determined quality of the character perfectly, and gives all of her frustrations a great comic quality. She's a very talented dramatic actress and this film suggests that she's an even better comic actress. Her timing is near perfect. And yes, she's devastatingly attractive and charming (was there any doubt there?). I hope this opens doors for her...

Second, the message. I happen to be a veteran of the pharmaceutical industry. I hope everyone can see this film and get a glimpse of the marketing practices of big pharma. It's fictional, obviously, but however hilariously absurd and gross the pharmaceutical industry may seems in this film, it's not an exaggeration. If you're in the medical profession or doing anything that is even remotely connected to medicine or pharmaceuticals it should be mandatory. Even if you're not - this affects us all.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
5 of 6 people found the following review helpful By I'd rather be at the Beach TOP 500 REVIEWER on October 28, 2013
Format: DVD Verified Purchase
As a Katherine Hiegl fan, I thought I had been fortunate to discover one of her earlier unknown gems. OMG, there is NO way this could be considered fortunate! She does a great job being charming and adorable as always, but the movie itself is horrible: horrible writing and the cinematography is so bad that it looks like it was filmed at home with someone's video cam in their basement. The sound is that bad, too. I paid next to nothing for it, so it the story had been at least WATCHABLE, it would have been worth it. This is just a really bad, really shameful effort at movie making. Avoid at all costs.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again


There are no discussions about this product yet.
Be the first to discuss this product with the community.
Start a new discussion
First post:
Prompts for sign-in

Set up an Amazon Giveaway

Amazon Giveaway allows you to run promotional giveaways in order to create buzz, reward your audience, and attract new followers and customers. Learn more
Side Effects
This item: Side Effects
Price: $24.99
Ships from and sold by

What Other Items Do Customers Buy After Viewing This Item?