Signaling Networks and Cell Cycle Control : The Molecular Basis of Cancer and Other Diseases (Cancer Drug Discovery and Development, 5) (Cancer Drug Discovery and Development) [Hardcover]

J. Silvio Gutkind (Editor)

Book Description

ISBN-10: 089603710X | ISBN-13: 978-0896037106 | Publication Date: April 1, 2000 | Edition: 1

Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

Editorial Reviews

Review

"Each chapter contains a well-referenced, clearly illustrated and up-to-date summary of the state of affairs including a discussion of the areas that are still open for further work. The volume provides a good read for both workers actively engaged in drug research as well as those working in the more fundamental areas of signaling and the cell cycle." - Cell Biology and Function

"...the range of topics included in this book is impressive....This volume works well on many levels. For graduate students struggling to assimilate the large body of signaling literature, the first half of the book offers what amounts to a comprehensive review of the most basic aspects of signal transduction. For experts, these same chapters serve as a point of departure for the second half, which deals with the emerging body of literature on how one can manipulate signaling pathways in the treatment of disease. It is the combination of basic and applied aspects of signal transduction that makes this book unique....the editor has done a remarkable job in selecting and assembling reviews from experts in signal transduction, and for presenting such a lucid discussion of this complex field." - Quarterly Review of Biology

"Each chapter is well referenced and stands alone as a comprehensive review in a specific area of signaling networks and cell-cycle control. In many cases the authors have highlighted several areas that are still open for further investigation, and have attempted to define the most likely molecular targets for pharmacological intervention...I would recommend this as a must have reference book, aimed mainly at an expert audience, which any good academic or biotechnological company library should have." - Cell Biology International

From the Back Cover

The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules.
Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

Product Details

• Hardcover: 592 pages
• Publisher: Humana Press; 1 edition (April 1, 2000)
• Language: English
• ISBN-10: 089603710X
• ISBN-13: 978-0896037106
• Product Dimensions: 10.2 x 7.2 x 1.3 inches
• Shipping Weight: 3.6 pounds (View shipping rates and policies)
• Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
• Amazon Best Sellers Rank: #2,499,156 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

1 of 1 people found the following review helpful:

5.0 out of 5 stars Two thumbs up., June 13, 2003

By 

Ahmed Fazly (Winona, MN United States) - See all my reviews

This review is from: Signaling Networks and Cell Cycle Control : The Molecular Basis of Cancer and Other Diseases (Cancer Drug Discovery and Development, 5) (Cancer Drug Discovery and Development) (Hardcover)

This book contains a collection of excellent reviews on various signalling molecules. It examines the most important singaling pathways in cells and provides an clear understanding of the differnt compenents of each pathway and their complex interactions. Excellent reference for any researcher interested in signaling and a great starting place for a comprehensive review on the topic of your interest. I approached this book as primer for signaling pathways before I embarked on graduate studies. It helped me a lot in gaining an understanding of the Wnt pathway, which I was interested in. However, the same can be accomplished by using reviews from peer reviewed journals. I think the the most wonderful thing about this book is that it covers most of the important signaling pathways extensively in a single volume. The drawback is that this is not an introductory text. Highly recommended for graduate students interested in signaling but who already have an understanding of the basic concepts.