Single-Channel Recording [Hardcover]

Bert Sakmann (Editor), Erwin Neher (Editor)

Book Description

ISBN-10: 030644870X | ISBN-13: 978-0306448706 | Publication Date: May 31, 1995 | Edition: 2nd

Edited by the 1991 winners of the Nobel Prize in Physiology or Medicine, this Second Edition includes new chapters covering such applications as capacitance measurements; single-cell PCR measurements; whole-cell recording from brain slices in combination with imaging techniques; atomic force microscopy of cells and membranes attached to glass pipettes; and patch clamping.

Editorial Reviews

Review

From reviews of the First Edition: "A landmark in the field of membrane biophysics." (Science) "A first-class laboratory guide...an indispensable reference." (Neuroscience)

Product Details

• Hardcover: 722 pages
• Publisher: Springer; 2nd edition (May 31, 1995)
• Language: English
• ISBN-10: 030644870X
• ISBN-13: 978-0306448706
• Product Dimensions: 9.4 x 6.4 x 1.7 inches
• Shipping Weight: 2.8 pounds (View shipping rates and policies)
• Average Customer Review: 4.8 out of 5 stars  See all reviews (5 customer reviews)
• Amazon Best Sellers Rank: #1,624,728 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

7 of 8 people found the following review helpful:

5.0 out of 5 stars The Patcher's Bible, March 30, 2000

By 

Keith Duncan (Baltimore, MD) - See all my reviews

This review is from: Single-Channel Recording (Hardcover)

Single Channel Recording is the possibly the single most useful text for the patch-clamp novice, and the text continues to be a fundamental resource for veterans. Sakmann and Neher, inventors of the technique, have compiled a book to give both theoretical background and practical advice regarding both experimental setup and data analysis. Whole-cell, single channels, and perforated patch are discussed. The practicalities of suitable patch glass, noise abatement, and capacitance cancelation are also covered. This book is a must have for all electrophysiologists.

1 of 1 people found the following review helpful:

4.0 out of 5 stars The most "complete" book on the subject yet, May 3, 2010

By 

Sandipan Chowdhury "sandy_ion" (Madison, WI USA) - See all my reviews
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Amazon Verified Purchase

This review is from: Single-Channel Recording (Paperback)

Simple, precise, easy to read and understand, methodical, plenty of explanation - the INDISPENSABLE HANDBOOK for patch clamp/single channel recording. It's one of the books that's a "must have" for all grads, post docs and scientists working on electrophysiology and am sure that everyone will have something to gain from it.

Only complaint - since single channel analysis so heavily relies on building on models, there needs to be more description on it. There are only a couple of chapters with very elementary model building stuff which isn't going to be of much help to people, except to the ones who are just starting out. (But that's just a personal opinion)

4 of 6 people found the following review helpful:

5.0 out of 5 stars A truly gripping read, December 7, 2005

By 

Syn Apse - See all my reviews

This review is from: Single-Channel Recording (Hardcover)

A frequent complaint about neuroscience books is that they are a bit dry, but I am pleased to report that "Single Channel Recording" is as taut and suspenseful a tale as has ever hit the mystery shelf. Jumping immediately into the action with Chapter one, "A Practical Guide to Patch Clamping", the book provides a sinister foreshadowing of hidden dangers yet to come. Will recording noise preclude detection of the crucial signals? Will junction potentials throw the investigation off completely? And what of poor Calcium?

I don't want to give away the explosive finale (although I will give a hint: dielectric membrane breakdown), but suffice it to say that by the time the book is over, you will be exposed to a bigger bag of tricks than was ever dreamed up by "Q branch" from the James Bond series (The analogy was obviously on the authors' minds, with direct references to the "Q matrix").

Not only is the plot crisp, but the writing is also highly satisfying and complex, sometimes with a whimsical air that vaguely recalls Vonnegut's "Breakfast of Champions" but other times with a cold analytical nature that more closely resembles Truman Capote's "In Cold Blood". The book is truly a masterpiece, and Neher and Sakmann work as well together as their Sesame Street namesakes. Dust off the shelves for another Nobel, boys, this time in literature!