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Single-Channel Recording (Perspectives on Individual) Hardcover – May 31, 1995

ISBN-13: 978-0306448706 ISBN-10: 030644870X Edition: 2nd

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Product Details

  • Series: Perspectives on Individual
  • Hardcover: 700 pages
  • Publisher: Springer; 2nd edition (May 31, 1995)
  • Language: English
  • ISBN-10: 030644870X
  • ISBN-13: 978-0306448706
  • Product Dimensions: 7 x 1.8 x 10 inches
  • Shipping Weight: 2.8 pounds (View shipping rates and policies)
  • Average Customer Review: 4.9 out of 5 stars  See all reviews (7 customer reviews)
  • Amazon Best Sellers Rank: #1,771,690 in Books (See Top 100 in Books)

Editorial Reviews

Review

From reviews of the First Edition:

"A landmark in the field of membrane biophysics." (Science)

"A first-class laboratory guide...an indispensable reference." (Neuroscience)


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12 of 14 people found the following review helpful By Syn Apse on December 7, 2005
Format: Hardcover
A frequent complaint about neuroscience books is that they are a bit dry, but I am pleased to report that "Single Channel Recording" is as taut and suspenseful a tale as has ever hit the mystery shelf. Jumping immediately into the action with Chapter one, "A Practical Guide to Patch Clamping", the book provides a sinister foreshadowing of hidden dangers yet to come. Will recording noise preclude detection of the crucial signals? Will junction potentials throw the investigation off completely? And what of poor Calcium?

I don't want to give away the explosive finale (although I will give a hint: dielectric membrane breakdown), but suffice it to say that by the time the book is over, you will be exposed to a bigger bag of tricks than was ever dreamed up by "Q branch" from the James Bond series (The analogy was obviously on the authors' minds, with direct references to the "Q matrix").

Not only is the plot crisp, but the writing is also highly satisfying and complex, sometimes with a whimsical air that vaguely recalls Vonnegut's "Breakfast of Champions" but other times with a cold analytical nature that more closely resembles Truman Capote's "In Cold Blood". The book is truly a masterpiece, and Neher and Sakmann work as well together as their Sesame Street namesakes. Dust off the shelves for another Nobel, boys, this time in literature!
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7 of 8 people found the following review helpful By Keith Duncan on March 30, 2000
Format: Hardcover
Single Channel Recording is the possibly the single most useful text for the patch-clamp novice, and the text continues to be a fundamental resource for veterans. Sakmann and Neher, inventors of the technique, have compiled a book to give both theoretical background and practical advice regarding both experimental setup and data analysis. Whole-cell, single channels, and perforated patch are discussed. The practicalities of suitable patch glass, noise abatement, and capacitance cancelation are also covered. This book is a must have for all electrophysiologists.
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2 of 2 people found the following review helpful By Sandipan Chowdhury on May 3, 2010
Format: Paperback Verified Purchase
Simple, precise, easy to read and understand, methodical, plenty of explanation - the INDISPENSABLE HANDBOOK for patch clamp/single channel recording. It's one of the books that's a "must have" for all grads, post docs and scientists working on electrophysiology and am sure that everyone will have something to gain from it.

Only complaint - since single channel analysis so heavily relies on building on models, there needs to be more description on it. There are only a couple of chapters with very elementary model building stuff which isn't going to be of much help to people, except to the ones who are just starting out. (But that's just a personal opinion)
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By Atek on May 14, 2013
Format: Paperback Verified Purchase
This book is Essential for students and researchers in the biophysical field. Ten stars, for many of reasons. Good price
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