For a cell to function normally, it must be able to maintain its total calcium content despite ionic variations in both the intracellular and extracellular environment. The sodium-calcium exchange provides a unique way to control net calcium flux by its capacity to transport calcium both into and out of the cell, which is important in the control of a variety of cellular functions, including contraction, secretion, and the regulation of photo-electric currents. Written by leading researchers in the field, this book provides the first comprehensive review of the sodium-calcium exchange system, from studies on intact cells and membrane vesicles to its isolation and molecular biology.
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