Solubility and Solubilization in Aqueous Media (American Chemical Society Publication) [Hardcover]

Samuel H. Yalkowsky (Author)

Book Description

Publication Date: November 18, 1999 | ISBN-10: 0841235767 | ISBN-13: 978-0841235762 | Edition: 1

This book aims to provide the reader with a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium. The book begins with the factors which govern solubility in general and then looks at aqueous solubility in particular, including the properties of liquid mixtures and the thermodynamics of solutions formed from mixing two components. The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media. It discusses in detail the most commonly used solubility enhancers: buffers, cosolvents, surfactants, and complexants. Each chapter is self-contained and emphasizes the details for applying the techniques.

Editorial Reviews

Review

"Provides a working knowledge of the various means of controlling the solubility and dissolution rates of drugs and other biologically active compounds. Begins by describing factors that govern solubility in general and aqueous solubility in particular, then outlines various techniques for altering solubility and dissolution rates of organic compounds. Covers most commonly used solubility enhancers, such as buffers, cosolvents, surfactants, and complexants. A conceptual basis for understanding the degree of solubilization of a solute is provided for each technique, along with examples using a number of real drugs. For new and experienced researchers in pharmaceuticals. The author is professor of pharmaceutical sciences at the University of Arizona."--SciTech Book News

About the Author

Samuel H. Yalkowsky is at University of Arizona.

Product Details

• Hardcover: 480 pages
• Publisher: American Chemical Society; 1 edition (November 18, 1999)
• Language: English
• ISBN-10: 0841235767
• ISBN-13: 978-0841235762
• Product Dimensions: 9.3 x 5.8 x 1.3 inches
• Shipping Weight: 2.2 pounds (View shipping rates and policies)
• Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
• Amazon Best Sellers Rank: #2,311,280 in Books (See Top 100 in Books)
  • #57 in Books > Professional & Technical > Professional Science > Chemistry > Molecular Chemistry

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Customer Reviews

Most Helpful Customer Reviews

5.0 out of 5 stars But where are the special AHAs?, April 1, 2003

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tommy_tads "tommy_tads" (London, UK) - See all my reviews

This review is from: Solubility and Solubilization in Aqueous Media (American Chemical Society Publication) (Hardcover)

Yalkowsky has written a gem here: quite possibly the best book on solubility in aqueous media I have read, and right up with the best on solubilization in the same. One of the interesting conundrums posed is: why do people float on the dead sea? But my favourite was where it was showed that James Bond would be unlikely entirely to dissolve if he were dropped in a vat of acid by Blofeld. Excellent.