In human genetic research sophisticated statistical methods are increasingly being used to analyse results. Until now there has been no book to introduce and explain these methods. The methods are based on both biology and statistics and are likely to contribute to major scientific and medical advances in the next century. Topics include the estimation of allele frequencies, the testing for Hardy-Weinberg equilibrium, classical and complex segregation analysis, linkage analysis for Mendelian and complex diseases and quantitative traits, the detection of allelic associations, the estimation of heritability for multifactorial traits and path analysis. An understanding of elementary statistical concepts is assumed, but the objectives, principles and limitations of the methods are discussed in detail.
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... an extremely valuable introduction...invaluable to new researchers in human disease genetics.. -- The Statistician, No. 47, 1998
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From the Back Cover
In human genetic research sophisticated statistical methods are increasingly being used to analyse results. Until now there has been no book to introduce and explain these methods. The methods are based on both biology and statistics and are likely to contribute to major scientific and medical advances in the next century. Topics include the estimation of allele frequencies, the testing for Hardy-Weinberg equilibrium, classical and complex segregation analysis, linkage analysis for Mendelian and complex diseases and quantitative traits, the detection of allelic associations, the estimation of heritability for multifactorial traits and path analysis. An understanding of elementary statistical concepts is assumed, but the objectives, principles and limitations of the methods are discussed in detail.
--This text refers to an out of print or unavailable edition of this title.
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Most Helpful Customer Reviews
7 of 8 people found the following review helpful:
4.0 out of 5 stars
Statistics in Human Genetics - Sham P,
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This review is from: Statistics in Human Genetics (Paperback)
This is an excellent book covering all major areas of genetic epidemiology. Ideal for postrgraduate studies it is well structured and highly detailed. The only criticism would be is that the sections on association studies and segregation analysis are not overly strong, but then this reflects the states of those fields in comparison to linkage analysis
2 of 2 people found the following review helpful:
3.0 out of 5 stars
Good book but Don't deserve!,
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This review is from: Statistics in Human Genetics (Paperback)
This is a good book on the state-of-art Human Genetics Statistics. However, first, the organization of the topics is not that systematical and is a bit chaotic, especially section on association analysis. The author just simply puts everything together without a clear connection among each part. Sometimes (actually most), the language is confusing. Large paragraphs were used try to clarify an issue, but appear to be the opposite to what one wishes. On the other hand, unfortunately, there are a lot a lot of TYPOs in the book!
My comment is: Don't deserve the price (actually it's going up!!!) and don't deserve a 'Bible' in the field!
5.0 out of 5 stars
Fantastic Book!,
This review is from: Statistics in Human Genetics (Paperback)
This book is a fantastic introduction to and reference to stats in genetics (I bought it for a genetic epidemiology course). Sham works through the concepts with enough detail that you aren't wondering what is going on, but so that you aren't bored either. The explanations are clear, the writing is excellent and the organization of the book can't be beat. Highly recommended.
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