Introduces a new, simplified classification for stereoselective reactions based on changes in the number of chiral centres taking place, emphasizing the three-dimensional representations of transition states in which stereoselectivity is determined. Using stereochemical vocabulary in accordance with IUPAC rules, it covers analysis of factors in which asymmetric induction occurs, the interplay between steric and electronic effects, the importance of conformational control, advantages of intramolecularity and the majority of important reaction types used in modern stereoselective synthesis.
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Book Description
Editorial Reviews
From the Back Cover
Stereoselective Synthesis considers the methods available for the synthesis of simple target molecules, the majority containing not more than two chiral centres, as single stereoisomers. This volume focuses on the factors which give rise to the stereoselectivity and classifies stereoselective reactions accordingly. This classification, and the extensive use of 3-D representations, enables the student to understand the stereochemistry of these reactions and hence apply them to the synthesis of previously unseen target molecules as single stereoisomers. Stereoselective Synthesis presents:
* a new, unique, simplified classification for stereoselective reactions based on the number of chiral centres created in the product by comparison with the number present in the starting material
* coverage of the majority of important reaction types used in modern stereoselective synthesis
* a detailed analysis of factors which bring about asymmetric induction: the interplay between steric and electronic effects, the importance of conformational control and the advantages of intramolecularity in reactions
* emphasis on synthesis of simple target molecules and on those steps which involve stereochemistry
* realistic 3-D representations of transition states in which stereoselectivity is created
* stereochemical vocabulary in accordance with IUPAC rules
Stereoselective Synthesis is an invaluable aid not only to students in understanding this important area but also to those actively engaged in the syntheses of target molecules as single stereoisomers.
* a new, unique, simplified classification for stereoselective reactions based on the number of chiral centres created in the product by comparison with the number present in the starting material
* coverage of the majority of important reaction types used in modern stereoselective synthesis
* a detailed analysis of factors which bring about asymmetric induction: the interplay between steric and electronic effects, the importance of conformational control and the advantages of intramolecularity in reactions
* emphasis on synthesis of simple target molecules and on those steps which involve stereochemistry
* realistic 3-D representations of transition states in which stereoselectivity is created
* stereochemical vocabulary in accordance with IUPAC rules
Stereoselective Synthesis is an invaluable aid not only to students in understanding this important area but also to those actively engaged in the syntheses of target molecules as single stereoisomers.
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Inside This Book
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First Sentence:
Organic synthesis requires the exercise of control in the way that organic molecules react. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
created chiral centre, one diastereoface, geometrical imperative, enantiopure reagent, existing chiral centre, inherent diastereoselectivity, enantiopure catalyst, chirality transfer reactions, prochiral element, two enantiotopic atoms, epoxidising agent, diastereoselectivity arises, diastereotopic atoms, diastereoisomeric transition states, reaction ensemble, adjacent chiral centres, transition state resembling, intramolecular delivery, diastereoisomeric products, double asymmetric induction, new chiral centre, endo diastereoselectivity, enantiopure form, chair transition state, single chiral centre Key Phrases - Capitalized Phrases (CAPs): (learn more)
Tetrahedron Lett, New York, Perkin Trans, Academic Press, Pure Appl, Pergamon Press, Tetrahedron Left, Asymmetric Synthesis, Plenum Press New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Organic synthesis requires the exercise of control in the way that organic molecules react. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
created chiral centre, one diastereoface, geometrical imperative, enantiopure reagent, existing chiral centre, inherent diastereoselectivity, enantiopure catalyst, chirality transfer reactions, prochiral element, two enantiotopic atoms, epoxidising agent, diastereoselectivity arises, diastereotopic atoms, diastereoisomeric transition states, reaction ensemble, adjacent chiral centres, transition state resembling, intramolecular delivery, diastereoisomeric products, double asymmetric induction, new chiral centre, endo diastereoselectivity, enantiopure form, chair transition state, single chiral centre Key Phrases - Capitalized Phrases (CAPs): (learn more)
Tetrahedron Lett, New York, Perkin Trans, Academic Press, Pure Appl, Pergamon Press, Tetrahedron Left, Asymmetric Synthesis, Plenum Press New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 32
books:
See all 32 books this book cites
5
books
cite this book:
- Frontier Orbitals and Organic Chemical Reactions by Ian Fleming on page 145, page 187, and page 313
- Total Synthesis of Natural Products: The Chiron Approach by Stephen Hanessian on page 76, and page 520
- Conservation of Orbital Symmetry by Richard B. Woodward on page 145, and page 187
- Organic Chemistry (Organic Synthesis Today and Tomorrow Series) (v. 4) by B. Trost on page 271, and page 313
- Stereochemistry of Carbon Compounds (Advanced Chemistry) by Ernest Ludwig Eliel on page 34, and page 271
See all 32 books this book cites
- Medicinal Chemistry: An Introduction by Gareth Thomas on page 467, and Back Matter
- Chirality in Industry II: Developments in the Commercial Manufacture and Applications of Optically Active Compounds by A. N. Collins on page 115
- Organic Synthesis Highlights IV (v. 4) by Hans-Günther Schmalz on page 46
- Principles and Applications of Stereochemistry by Michael North on page 224
- Process Chemistry in the Pharmaceutical Industry by Kumar Gadamasetti on page 320
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