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Stop Depression Now: SAM-e: The Breakthrough Supplement that Works as Well as Prescription Drugs Mass Market Paperback – September 1, 2000


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Product Details

  • Mass Market Paperback: 288 pages
  • Publisher: Berkley Trade (September 1, 2000)
  • Language: English
  • ISBN-10: 0425176436
  • ISBN-13: 978-0425176436
  • Product Dimensions: 7.9 x 5.1 x 0.8 inches
  • Shipping Weight: 8.5 ounces
  • Average Customer Review: 3.9 out of 5 stars  See all reviews (33 customer reviews)
  • Amazon Best Sellers Rank: #734,930 in Books (See Top 100 in Books)

Editorial Reviews

Amazon.com Review

SAM-e (pronounced "sammy"), short for S-adenosyl-methionine, will revolutionize the treatment of depression in the U.S. as it has for two decades in Europe, claim authors Richard Brown and Teodoro Bottiglieri. Not an herb, not a prescription drug, SAM-e is an over-the-counter natural supplement that has undergone extensive testing and has just become available in the U.S. "Study after study has confirmed that SAM-e works as well as or better than any other antidepressant," say the authors. It also works faster and with far fewer side effects, and it seems to help osteoarthritis and fibromyalgia as well.

Stop Depression Now is more than a book about SAM-e. It also presents a four-step program to lift you out of depression and prevent a recurrence. Step 1 is a self-assessment test to determine the severity of your depression. Step 2 includes information on how to use SAM-e. Step 3 is a diet plan that emphasizes foods and vitamins that will help you feel better (and avoid those that will make you feel worse). Step 4 offers lifestyle changes and therapeutic techniques to help you in the long term.

The authors' credentials show that they know their subject: Richard Brown is an associate professor of clinical psychiatry at Columbia University College of Physicians and Surgeons, a psychiatrist in private practice, and a research physician; Teodoro Bottiglieri is a senior research scientist, director of neuropharmacology, and associate professor at Baylor University Medical Center, and has been studying SAM-e for 15 years.

If you are severely depressed or suicidal, have a history of drug or alcohol abuse, or are already taking an antidepressant, confer with your health professional before taking SAM-e--do not self-treat. Otherwise, the authors certainly make this supplement sound like a breakthrough tool for depression. --Joan Price --This text refers to an out of print or unavailable edition of this title.

From Kirkus Reviews

A heavy-duty plug for a nutritional supplement as treatment for depression; however, the plug is reasonably placed within the framework of an informative, even-handed discussion of depression, its diagnosis, and treatment. Psychiatrist Brown, of the Columbia University College of Physicians and Surgeons, uses both conventional medications and alternative therapies in his practice. Here he joins forces with neuropharmacologist Bottiglieri (Baylor Univ.) to argue for the use of a substance called SAM-e, available over-the-counter, for the treatment of mild to moderate depression. They make clear at the outset that ``anyone who is depressed, suicidal, or has a history of drug or alcohol abuse must be treated by a competent professional. Self treatment is not an option.'' They go on to explain what depression is and what SAM-e is (a substance naturally found in the human body, currently much more widely used in Europe than in the US), and look at the myriad other drugs used to treat depression. Throughout, the authors cite numerous research studies, reported in reputable professional journals (from 1972 to the present, with a complete list in the bibliography) to support their views. They then lay out a program for treatment, beginning with ``Assess Your Mood'' (using an established diagnostic tool); and including improved nutrition to support the therapy, and establishing a healthier lifestyle. A reasonable guide to the current state of affairs in treating depression, then, with a still unorthodox recommendation for treatment that sufferers might discuss with their physicians. -- Copyright ©1999, Kirkus Associates, LP. All rights reserved. --This text refers to an out of print or unavailable edition of this title.

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Customer Reviews

No miracle cure here folks.
Ernest N Passeos II
Sure, my mood was normal a few days later, but studies have shown that the condition causes permanent cognitive dysfunction.
Henry J. Sokolowski
I happened upon this book and found the information very accessable.
Malcolm G. Sands

Most Helpful Customer Reviews

67 of 67 people found the following review helpful By A Customer on August 5, 1999
Format: Hardcover
I took Dr. Brown's advice and used sam-e. I had had some success in treating my chronic depression with wellbutrin, but oppressive feelings of sadness, and self-destructive ideation, remained. One week of 200mg sam-e two times daily and the oppressive feelings began to lessen. In two weeks the bad feelings had remitted completely. Though effective, sam-e was mild in its action -- I did not feel that I had been clubbed by a mega-drug. Feeling well, I am able now to have better insight into life problems linked to my long depression -- and I'm able to work on repairing family relationships that had been damaged. I recommend that anyone suffering from depression try sam-e. Reading Dr. Brown's book is an excellent way to learn about this substance.
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60 of 60 people found the following review helpful By A Customer on January 10, 2000
Format: Hardcover
With the recommendation and supervision of my psychiatrist, I have been taking SAM-e for several months. Not only has the recurring major depression I have had since childhood departed, but the fibromyalgia/CFS and arthritis pain in my hands have disappeared too!
I am actually stunned by these wonderful results! Over many years, well-meaning psychiatrists have prescribed medications for me which not only didn't work, but made my life a living hell from side effects in the process. In contrast, the only discomfort I have experienced from SAM-e is a slight upset stomach shortly after taking it.
Dr. Brown and the others have written a clear guide to SAM-e and how to use it to improve the health of mind and body. I highly recommend this book to those suffering from depression, arthritis, fibromyalgia, and chronic fatigue syndrome.
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45 of 46 people found the following review helpful By A Customer on August 3, 1999
Format: Hardcover
As a high-functioning professional who has suffered from recurring, only partially remitting depression for about 30 years, I was totally amazed when SAM-e supplements (combined with a low dose of Prozac) suddenly helped me. I heard about it from my shrink, who suggested it somewhat tenatively. So I read the book. The book is somwhat simplistic, and I would have preferred a more detailed, scientific analysis. But the bottom line was that SAM-e seemed safe and worth a try. To my surprise in 2 days, at suggested doses of 400 mg a day, I felt at least 50% better. I have since gone up to 800 mg a day with no side effects, only an almost complete wipe-out of the depression. Believe me, I have tried all the prescription and non-prescription remedies in the universe before this, including Prozac by itself. A cloud has lifted off of me. I just hope that others can have the same relief. I hope to hear from you if you have tips, warnings or anecdotes to share.
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39 of 40 people found the following review helpful By A Customer on September 5, 1999
Format: Hardcover
I'm an American psychiatrist and psychotherapist working in London. Having heard Dr. Brown talk about SAMe at a lecture to psychiatrists, I ordered Stop Depression Now when it came out, and read it. The authors' view that SAMe is an effective antidepressant without significant toxicity impressed me as having a scientific basis. I recommended to two patients of mine that they try it. One, who was not clinically depressed, but was feeling unfulfilled at work and was having trouble sleeping, took 200 milligrams twice a day. She noted that within a few days she felt happier, had more energy, and fell asleep more easily. The second patient had had the insidious onset a few years earlier of intermittent feelings of pins and needles in his hands and feet. These had been growing more evident, especially in his feet. I suggested that he take a cocktail that this book recommends: SAMe 400 milligrams a day, Vitamin B12 one milligram a day, and folic acid 800 micrograms a day. Over the past few weeks the feelings in his extremities have disappeared. He, too, has said he feels more energy and feels happier. Neither patient has experienced any side effects. I am favorably impressed by these two anecdotes. I hope some of my colleagues will investigate the merits of SAMe, Vitamin B12, folic acid, and the diet that the book recommends, and report their findings.
Morton Schatzman, MD
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32 of 34 people found the following review helpful By Malcolm G. Sands on July 24, 2000
Format: Hardcover
Having tried a variety of antidepressants and suffered too many side effects, I feel relatively knowledgeable about treatment options. I happened upon this book and found the information very accessable. Dr. Brown and his associates have presented a well researched and well organized book. I would recommend that others with low level depression that is too hard to shake off but who are hesitant about taking prescription meds to give SAM-e a try. Read over his book and find out for yourself. There are sites that offer this product, however i have settled on iHerb because of the documentation offered as well as the variety of brands and dosages. Read, research and try for yourself what I mean.
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40 of 45 people found the following review helpful By Bart Tare on October 21, 2001
Format: Mass Market Paperback
I tried SAM-e over a four month period (September-December 2001)and found it to be somewhat, but not completely effective in relieving my anxiety and depression. At first, for a few weeks at least, I felt that SAM-e was giving me a moderate antidepressant-type relief for the constant tension I seem to carry around in my body. However, after this time, I either adjusted to SAM-e or its effects became less noticable to me and I started to feel like it was not working. I had that same feeling each time I stopped and started SAM-e over the four month period. For me, SAM-e is more effective than St. John's wort, kava, and Omega-3s, though I'm not sure how it compares to 5-HTP, as my experience has been mixed with that stuff. However, SAM-e has not been as powerful and effective on me as SSRIs in its antidepressant effect. But, SAM-e appears to have no SSRI-like side effects, which is certainly pleasant. And, according to Brown and others, SAM-e may even have some health benefits. In terms of Richard Brown's book, I found it to be OK, nothing special, nothing I haven't read (or tried) before about/for treating depression. He briefly discusses SSRIs, MAO inhibitors, tricyclics, St. John's wort, cognitive behavioral techniques, diet, essential fatty acids, exercise, yoga, and meditation. These things are all helpful, but are presented in greater detail in other books. And, in light of my experience with SAM-e, maybe Stop Depression Now is tad bit over-optimistic about this stuff as a miracle drug. Also, I still didn't feel like the studies Brown quotes in this book were large enough or done on a long-term enough scale to know if SAM-e is truly safe or not. It sounds good and Brown is convincing, but my experience with SAM-e has so far told me otherwise.
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