This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.
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Editorial Reviews
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?In this book, Lednicer presents a detailed discussion of strategies toward the synthesis of pharmaceutical compounds. . . The strength of the book is the wealth of data collected in one relatively short tone?.
From the Publisher
The field of organic synthesis has influenced chemistry and in turn society in a profound number of areas, from the development of medicinal agents to an astonishing variety of polymers. This book focuses upon the strategies and organic transformations which have been used to prepare the various structural classes that have been investigated as drugs. Special attention is paid to clarifying individual reactions of the drugs, and the text includes an extensive "Reaction Index."
--This text refers to an out of print or unavailable edition of this title.
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This review is from: Strategies for Organic Drug Synthesis and Design (Hardcover)
For impartial reviews of this book check:- C.J. Spagnuolo, Journal of Medicinal Chemistry, 1999, 42:1113 - G. O'Sullivan, Synthesis, 1999, 6:1084
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Inside This Book
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Key Phrases - Statistically Improbable Phrases (SIPs):
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miscellaneous compounds, enol chloride, internal imine formation, pyrrazole ring, lithio reagent, potentiating groups, arylacetic and arylpropionic acids, nucleophilic aromatic displacement, imino chloride, enone function, lower side chain, catalytic hydrogenation over palladium, cyclodehydration reaction, basic ether, ethanolic hydrogen chloride, tertiary carbinol, diaxial opening, carbethoxy group, methyl orthoformate, benzyl protecting group, benzofuran ring, more strenuous conditions, bond reorganization, acylation product, adjacent amine Key Phrases - Capitalized Phrases (CAPs): (learn more)
Drugs Future, German Patent, Tetrahedron Lett, Second Edition, Chronicles of Drug Discovery, John Wiley, European Patent, New York, British Patent, United States, Japanese Patent, Belgian Patent, Van Cutsem Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
miscellaneous compounds, enol chloride, internal imine formation, pyrrazole ring, lithio reagent, potentiating groups, arylacetic and arylpropionic acids, nucleophilic aromatic displacement, imino chloride, enone function, lower side chain, catalytic hydrogenation over palladium, cyclodehydration reaction, basic ether, ethanolic hydrogen chloride, tertiary carbinol, diaxial opening, carbethoxy group, methyl orthoformate, benzyl protecting group, benzofuran ring, more strenuous conditions, bond reorganization, acylation product, adjacent amine Key Phrases - Capitalized Phrases (CAPs): (learn more)
Drugs Future, German Patent, Tetrahedron Lett, Second Edition, Chronicles of Drug Discovery, John Wiley, European Patent, New York, British Patent, United States, Japanese Patent, Belgian Patent, Van Cutsem Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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