This volume is a statement of the scientific basis and rationale for surgical treatment of Parkinson's disease. It seeks to provide clinicians with a thorough understanding of when and why various surigical approaches are effective and offers guidelines on the selection of patients for surgery. The first two sections describe the anatomy and functional organization of the normal base ganglia and the pathophysiology of the basal ganglia in Parkinson's disease. The second half of the book examines various surgical procedures on structures of the basal ganglia involved in Parkinson's disease. The contributors explain the influence of clinical presentation on selection of a surgical target and discuss the indications and expected results of pallidotomy, chronical cerebral electrical stimulation, and grafting and lesoining procedures. Also included is a chapter on the rationale for subthalamotomy and other surgical targets. The book concludes with a discussion on selection of patients for surgery and clinical outcome.
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