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Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches [Kindle Edition]

Michael E. Burczynski , John C. Rockett
5.0 out of 5 stars  See all reviews (1 customer review)

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  • Print ISBN-10: 0849328403
  • Print ISBN-13: 978-0849328404
  • Edition: 1

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Book Description

Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach have appeared in the scientific press. One of the first publications on this topic, Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches describes initial applications and considerations for "omic" technologies in the field of surrogate tissue analysis.

Highlighting important issues to consider when conducting profiling studies to identify novel biomarkers, the first section covers transcriptional approaches in surrogate tissues. It provides a review of important issues in peripheral blood profiling, summarizes results achieved when evaluations of various blood preparation platforms are used for the purpose of transcriptional profiling, and covers the relatively novel application of transcriptional profiling in neurological and oncological disease settings. The second section focuses on proteomic and protein-based methods for identifying markers in surrogate tissues, highlighting immunoassay and mass-spectrometry approaches for assessment of proteins in serum and other fluids, with a focus on the implications of protein-based biomarkers for detecting and monitoring early stages of cancer. The third section explores metabolomic approaches along with other novel molecular screens that can be applied in surrogate tissues to find biomarkers, and examines in detail the rapid development of metabolomics into a powerful technique for biomarker identification.

The authors conclude with coverage of regulatory considerations, economic impact, and pan-omic strategies which will undoubtedly impact surrogate tissue analysis in the future. They explore current concepts in pan-omic approaches during drug development where a compendium of data generated by multiple profiling approaches are assessed and evaluated with its impact on the field of systems biology. The last chapter rounds out the coverage with a brief look ahead towards future analytical issues that will likely arise in the field of surrogate tissue analysis. The book is both an introduction to the various "omic" technologies in this young field and a fundamental reference for scientists interested in identifying biomarkers in surrogate tissues.

Editorial Reviews

Review

In summary, the editors and their coauthors have done a very
creditable job of expressing the breadth of the field of surrogate
tissue analysis and provide many concrete examples of techniques
for analysis. The treatment of this arising technology is
at once learned and practical with examples of success and of
the need for further research. The chapters at the end with perspective setting essays on economic and regulatory needs may
help some not accustomed to these issues to understand the issues.
However, the lesson to take away from this text is the great
possibilities that exist to sharpen our view of biology and of
medicine in particular. Future progress will involve refinement
of the methods described here. There are methods that will not
stand the test of time but taken as a whole, this book should
be widely read. Every chapter has extensive bibliographic references
and should serve as entrée into the literature even if the
specific examples are of only passinginterest. The editors and
their coauthors are to be commended in providing a very thorough
and interesting sampling of the methods being developed
in the field.
Sid Aaron, Sid Aaron Consultants, LLC, in the International Journal of Toxicology, May 2006

Product Details

  • File Size: 4536 KB
  • Print Length: 328 pages
  • Publisher: Informa Healthcare; 1 edition (November 10, 2005)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B001E77H68
  • Text-to-Speech: Enabled
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5.0 out of 5 stars A Report on Today's State of the Art June 2, 2006
Format:Hardcover
Surrogate Tissue Analysis, which strangely enough doesn't usually work with tissues, is a relatively new field where research is proceeding at a very rapid pace. So rapid, that even peer reviewed papers are in short supply. In this book, the authors, both active researchers in the field have written (four articles) or selected 18 articles written by researchers from around the world.

That makes this book just about the only choice for an introduction to the field. It is broken into five sections: Introduction, Genomic Approaches, Proteomic Approaches, Metabolomics and Other Approaches, Future Considerations. As such, it summarizes the field, reports on very recent research and gives some indications where research will be going in the next few years.

Besides the technical aspects, the book also reports on regulatory considerations, economic impact, and strategies in other '-omics' that may lead to new research areas.

This is the state of the art as it exists today.
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