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Systems Biology in Practice: Concepts, Implementation and Application [Hardcover]

Edda Klipp (Author), Ralf Herwig (Author), Axel Kowald (Author), Christoph Wierling (Author), Hans Lehrach (Author)
2.5 out of 5 stars  See all reviews (2 customer reviews)


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Book Description

May 6, 2005 3527310789 978-3527310784 1
Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation.

It provides readers with guidance on how a specific complex biological question may be tackled:

  • How to formulate questions that can be answered
  • Which experiments to perform
  • Where to find information in databases and on the Internet
  • What kinds of models are appropriate
  • How to use simulation tools
  • What can be learned from the comparison of experimental data and modeling results
  • How to make testable predictions

The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.



Editorial Reviews

Review

"...this is one book that I bought for myself as soon as it was published." (British Journal of Occupational Therapy, February 2008)

"This resource does an admirable job of bringing the readers to a level where they can pursue more advanced study and research." (IEEE Engineering in Medicine and Biology Magazine, January/February 2008)

"This rapid survey of a developing field is ideal for beginning graduate students…" (CHOICE, December 2005)

"This is a timely volume that should be welcomed both by practising systems biologists and by newcomers to the field.... I expect to consult it regularly over the foreseeable future, and I am confident that biologists everywhere will benefit from having a copy to hand." (Theoretical Biology and Medical Modelling)

"The authors manage to cover an astoundingly wide range of topics and to present the great potential of systems biology to the reader. The first introductory part makes it an ideal book for researchers from neighbouring disciplines, who benefit from the compact and clearly written basics in biology and mathematics. But the main area of application will be as textbook for the growing number of students interested in bioinformatics, systems biology and theoretical biology. With its 14 chapters, 450 pages and many diagrams and examples it provides plenty of material for lecturing." (Arzneimittel-Forschung/Drug Research)

From the Back Cover

Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation. It provides readers with guidance on how a specific complex biological question may be tackled:
  • How to formulate questions that can be answered
  • Which experiments to perform
  • Where to find information in databases and on the internet
  • What kinds of models are appropriate
  • How to use simulation tools
  • What can be learned from the comparison of experimental data and modeling results
  • How to make testable predictions.

The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.


Product Details

  • Hardcover: 485 pages
  • Publisher: Wiley-VCH; 1 edition (May 6, 2005)
  • Language: English
  • ISBN-10: 3527310789
  • ISBN-13: 978-3527310784
  • Product Dimensions: 9.5 x 6.8 x 1.1 inches
  • Shipping Weight: 2.3 pounds
  • Average Customer Review: 2.5 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Best Sellers Rank: #1,863,813 in Books (See Top 100 in Books)

 

Customer Reviews

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Average Customer Review
2.5 out of 5 stars (2 customer reviews)
 
 
 
 
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29 of 34 people found the following review helpful:
1.0 out of 5 stars I can not recommend this book!, January 22, 2006
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This review is from: Systems Biology in Practice: Concepts, Implementation and Application (Hardcover)
I thought a while before I started to write this review about how many points I should give. Does it realy deserve zero points? In my opinion, yes! (the rating system does not allow zero points)

I bought this very expensive book, written by five authors, and had so far no fun reading it nor does it provide valuable insights about currently the hot topic in biology. Let me just give some examples to make my point clear. First, not all chapters are written equal good/bad but differ. This implies that the five authors separated the chapters under each other. Chapter 4, "Experimental Techniques in a Nutshell" represents probably the negative highlight of the book. The author who has wirtten this chapter refuses persistenly to come to the point. I have to admit that it is almost impossible to explain mass spectromety, RNAi or DNA chips comprehensible if one has only one page for each of these topis. But is this not clear beforehand? This is a general problem of the book. It covers a huge list of differnt topics but the explanations of each topic is only shallow. Further examples for this: Baysian Networks, one page. Multiple linear regression, one page. Cell Cycle, one page. Ok, now we found a general law according to this the book was written. Compile a list of buzz words, order them in a meaningful way, and wirte one page to each of those terms. Finally, lets call it "Systems Biolog" and we are done. I don't think so, that's not it!

The only people this book could be useful for are undergraduate students who know nothing at all about this subject and want to get an overview about the topics collected under the phrase systems biology. But even for this reason one can not really recommend this book because it is far too expensive.

A final remark. It is clear, that books above the 100$ threshold deserve to be evaluated stronger because it hurts too buy them. If this book would cost 20$ I would give one point.
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8 of 10 people found the following review helpful:
4.0 out of 5 stars A nice book that covers a lot, March 15, 2006
This review is from: Systems Biology in Practice: Concepts, Implementation and Application (Hardcover)
I'm studying biophysics and I recently bought the book "Systems Biology

in Practice". It is quite expensive, but I wanted to read up about Systems

Biology, since we currently discuss this in our Bioinformatics lectures.

The book consists of three major parts, the first contains three introductory

chapters about biology, mathematics and experimental techniques, the second

is the main part which contains 8 chapters that describe mathematical models

of many different biological processes like gene expression, biological

oscillations or signal transduction pathways. The last part has two chapters

that deal with databases and software tools that are available over the

internet.

I personally found the "Biology in a Nutshell" chapter very helpful, since

my biological knowledge had several gaps and the chapter is a very condensed

presentation of the most important biological facts. I think it is also

the main aim of the three chapters about biology, mathematics and

experimental techniques to provide people coming from different fields with

some basic information about those topics.

All in all the book covers a large variety of different topics and the models

and information is presented with helpful examples and figures, so that I

find it quite entertaining to read.

My only point of critique is that I'm still not sure what systems biology is,

since there seems to be no generally accepted definition. However, I found

the book very useful to understand mathematical modelling of biochemical

systems and I use it often as reference book.
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Inside This Book (learn more)
First Sentence:
Life is one of the most complex phenomena in the universe. Read the first page
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Nucleic Acids Res, New York, Petri Nets, Lehrach Copyright, Genome Res, Pacific Symposium, Microsoft Windows, Oxford University Press, Gga Hsa, Cambridge University Press, Nature Genetics, San Francisco, Cell Cycle Res, Genes Dev, Invalid Gene, Other Mathematical Models of Evolution, Trends Genet, Using Bayesian
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