About the Author
For more than a quarter of a century, author and editor Dr. V. Craig Jordan has been involved with finding a cure for breast cancer. He has pioneered the evolution of ICI 46,474 from its birth in the laboratory to what is today tamoxifen--the world's most-prescribed drug for the treatment of breast cancer, and the only drug in FDA history approved for the prevention of breast cancer. Dr. Jordan is the recipient of numerous awards, including the prestigious Block Award for Distinguished Achievement in Cancer Research, the Inaugural Brinker International Award for Breast Cancer Research, and the American Society for Pharmacology and Experimental Therapeutics Award for Research on Human Disease. He has also been named Laureate of the Cino del Duca Award for Oncology in Paris (1997).
Excerpt. © Reprinted by permission. All rights reserved.
(from Chapter 15) "It is now apparent that there are two very different levels of risk in women with family histories of breast cancer; one due to a genetically inherited predisposition, and the other associated with an increased familial incidence of breast cancer. At present, mutations in three genes--P53, BRCA-1, and BRCA-2--have been associated with a genetic predisposition to breast cancer." (from Chapter 18) "Five years of tamoxifen reduces the incidence of primary (new) breast cancer in the contralateral breast by 50%. However, the effects of tamoxifen continue to protect the breast even after the drug is stopped."