This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
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The sequencing of the human genome has offered a genetic description of the entire repertoire of human genes, including a subset of disease targets. Despite this knowledge, now publically available, clinical pipelines are not yet enriched in drugs derived from targets emanating from this massive sequencing effort. A major concern for researchers in the biotechnology and pharmaceutical industries is how to choose the most likely targets for drug discovery and how to validate them.
Target Validation in Drug Discovery describes the background for the choice of target for several successful biological drugs (protein therapeutics). It offers excellent analyses of the underlying biology, the establishment of relative assays, and the translation to clinical trials of these drugs. Professionals in biotechnology and pharmaceutical drug discovery, clinical development, students, and academics in related areas of study will find this a unique reference for years to come.
. Includes detailed descriptions of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics
. Takes a look at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin
. Additional targets known as "second generation" drugs are covered and present new possible small molecule therapeutics
. Details approaches to design of orally active drugs against new disease mechanisms
. Contains contemporary technologies in drug discovery and case histories of successful drugs
Target Validation in Drug Discovery describes the background for the choice of target for several successful biological drugs (protein therapeutics). It offers excellent analyses of the underlying biology, the establishment of relative assays, and the translation to clinical trials of these drugs. Professionals in biotechnology and pharmaceutical drug discovery, clinical development, students, and academics in related areas of study will find this a unique reference for years to come.
. Includes detailed descriptions of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics
. Takes a look at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin
. Additional targets known as "second generation" drugs are covered and present new possible small molecule therapeutics
. Details approaches to design of orally active drugs against new disease mechanisms
. Contains contemporary technologies in drug discovery and case histories of successful drugs
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cetuximab therapy, inactivation cassette, cetuximab treatment, gatekeeper pocket, gene trap event, trastuzumab resistance, gene targeting projects, trapped gene, infliximab maintenance therapy, target validation studies, trastuzumab therapy, kinase selectivity, gene trapping, tissue influx, gene trap vector, trapping component, growth factor receptor monoclonal antibody, homology arms, growth factor receptor antibody, lamina propria mononuclear cells, gene knockdown, antibody cetuximab, selection cassette, macrophage influx, targeting efficiency Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Academic Press, Kidney Int, Cancer Inst, Drug Discovery Copyright, Cell Biol, New York, Arthritis Rheum, United States, Genes Dev, Humana Press Inc, Lippincott Williams, Cancer Biol, Cell Res, Cytokine Netw, Hirata Terra, Hrabe de Angelis, Trends Biochem New!
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Front Cover | Table of Contents | First Pages | Index | Surprise Me!
cetuximab therapy, inactivation cassette, cetuximab treatment, gatekeeper pocket, gene trap event, trastuzumab resistance, gene targeting projects, trapped gene, infliximab maintenance therapy, target validation studies, trastuzumab therapy, kinase selectivity, gene trapping, tissue influx, gene trap vector, trapping component, growth factor receptor monoclonal antibody, homology arms, growth factor receptor antibody, lamina propria mononuclear cells, gene knockdown, antibody cetuximab, selection cassette, macrophage influx, targeting efficiency Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Academic Press, Kidney Int, Cancer Inst, Drug Discovery Copyright, Cell Biol, New York, Arthritis Rheum, United States, Genes Dev, Humana Press Inc, Lippincott Williams, Cancer Biol, Cell Res, Cytokine Netw, Hirata Terra, Hrabe de Angelis, Trends Biochem New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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