Dix années se sont écoulées depuis que John Connor a sauvé l'humanité de la destruction totale. Désormais âgé de 22 ans, il vit clandestinement, sans foyer, sans travail, sans identité. Vivre sans laisser de traces est la seule façon dont John peut échapper à Skynet, le réseau global ultrasophistiqué de machines qui a déjà tenté de le tuer et de déclarer la guerre au genre humain. Mais voilà que les machines de Skynet parviennent à retrouver sa trace. Ils envoient alors vers le passé la T-X, une androïde nouvelle génération quasi invulnérable, pour éliminer le futur leader de la résistance humaine. Le seul espoir de survie de John repose sur le Terminator, son ancien ennemi...
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A decade has passed since John Connor (Nick Stahl) helped prevent Judgment Day and save mankind from mass destruction. Now 25, Connor lives "off the grid" - no home, no credit cards, no cell phone and no job. No record of his existence. No way he can be traced by Skynet - the highly developed network machines that once tried to kill him and wage war on humanity. Until out of the shadows of the future steps the T-X (Kristanna Loken), Skynet's most sophisticated cyborg killing machine yet. Sent back through time to complete the jobe left unfinished by her predecessor, the T-1000, this machine is as relentless as her human guise is beautiful. Now Connor's only hope for survival is the Terminator (Arnold Schwarzenegger), his mysterious former assassin. Together, they must triumph over the technologically superior T-X and forestall the looming threat of Judgment Day or face the apocalypse and the fall of civilization as we know it.