Over the last century, thousands of people have gone missing. Suddenly and inexplicably, 4400 missing people are returned, all at once, exactly as they were on the day they vanished. Unclear what this world-altering event means, the government investigates the 4400 to piece together where they've been and why they've been returned. It quickly becomes apparent that their presence will change the human race in ways no one could have foreseen.
A year has passed since 4400 abductees were returned to Earth (and six months since the original series ended). Richard (Mahershalalhashbaz Ali), Lily (Laura Allen), and Isabelle are on the run from Jordan Collier (Billy Campbell) and others who would attempt to harm their child. Shawn (Patrick Flueger) has moved into Collier's cult-like 4400 Center. Then there are NTAC (National Threat Assessment Command) agents Diana (Jacqueline McKenzie) and Tom (Joel Gretsch). The former has officially adopted Maia (Conchita Campbell), while the latter is reunited with formerly comatose son Kyle (Chad Faust), Shawn's best friend. Almost everyone, returnees and otherwise, is changing. Jordan, for instance, is having more seizures (as a result of his first encounter with the eerie Isabelle), while Kyle is having blackouts. Along the way, new characters are introduced, like mute mental patient Kevin (Jeffrey Combs, Re-Animator), who regains the ability to talk, thanks to Tess (Summer Glau, Serenity), the only returnee who can recall what happened to her. Others include Diana's sister April (Natasha Gregson Wagner), Jordans pal Matthew (Garret Dillahunt, Deadwood), and former NTAC supervisor Dennis Ryland (Peter Coyote), who returns to the fold. Guest stars include E.R.'s Sharif Atkins ("Voices Carry"), Star Trek: Voyager's Robert Picardo ("Weight of the World"), and Twin Peaks' Sherilyn Fenn ("Carrier"). The season will end much as the miniseries began, with the 4400 being released from another quarantine, setting the scene for the next year. Although the first set was a barebones release, the second features commentary from McKenzie, Gretsch, writer Craig Sweeny, and writer/producer Ira Steven Behr. --Kathleen C Fennessy