Three months ago I was as skeptical as John (below). I have OA in both knees and was contemplating knee replacement surgery. I decided to give this guy's recommendations a chance as a last resort, since my meds weren't helping much. I've been on fairly large doses of glucosamine/chondroitin, ASU, SAMe, and Omega 3-6-9 since around last Thanksgiving. My knee pain has reduced by, I would guess, about 75%. I don't want to over-hype this regimen, and I don't have any idea how long the relief will last. But it's real, and it's substantial. Note that you have to allow a couple of months for it to fully kick in. [...]
The above review was originally written on 2/14/07. As of 6/7/07, I've added the supplement MSM, and the "cocktail" continues to work. I'm still off pain meds except for the occasional ibuprofen. The supplements aren't magic, my knees continue to hurt, but I'm still much closer to pain-free than before I began the regimen. And most importantly, I'm still avoiding the surgeon's knife. ~CPW
EDIT AS OF 9/15/11: (REVIEW CHANGED FROM FIVE STARS TO FOUR) I underwent double knee replacement surgery on 4/25/11. The book's recommendations probably postponed the surgery by a few years, but once both knees were bone-on-bone, there was really no alternative. And now, 4+ months after the surgery, I'm nearly pain-free.
One more recommendation: If both knees are bad, and if your surgeon agrees, have them both done at the same time. The rehab is sheer hell for a month to six weeks, but two new knees don't hurt much more than one. Had I not made that decision, I might have tried to limp around on one good knee for the rest of my life (I'm 67), rather than endure another rehab. ~CPW