**I am pleased that Dr. Mukherjee has won the Pulitzer prize in general non fiction for this book, 4-18-11
In the United States one in three women and one in two men will develop cancer in their lifetime. Dr Siddhartha Mukherjee, a medical oncologist, has written a definitive history of cancer. It may be one of the best medical books I have read. Complex but simple in terms of understanding. A timeline of a disease and those who waged the wars. In 1600 BC the first case of probable breast cancer was documented. In the thousands of years since, the Greek word, 'onkos', meaning mass or burden, has become the disease of our time. Cancer. The title of the book, is "a quote from a 19Th century physician" Dr Mukherjee had found inscribed in a library book that "cancer is the emperor of all maladies, the king of our terrors".
As a health care professional and as a woman who is six years post breast cancer, Cancer has played a big part in my life. I used to walk by the Oncology clinic, and quicken my pace. I used to give chemotherapy to my patients, before it was discovered that the chemo was so toxic that it needed to be made under sterile conditions and given by professionals who specialized in Oncology. Dr Mukherjee, wisely discusses cancer in the context of patients, those of us who suffer. After all it is because of the patients, the people who have gone before us, who have contracted some form of cancer, they are the base of this science.
Dr Mukherjee started his immersion in cancer medicine at the Dana Farber Cancer Institute in Boston. He relates the beginning of the study of ALL, Acute Lymphocytic Leukemia, by Dr Sidney Farber in 1947. Dr Farber, a pathologist at the time decided to change his focus and start caring for patients. He was given a medication to trial for ALL, and though most of his patients died, some survived to remission. This opened his world and with the help of Mary Lasker, and Charles E Dana, philanthropists, they opened one of the first clinics that specialized in cancer care and research, The Dana Farber Cancer Center. Dr Mukherjee gives us the timeline of ALL and lymphomas and the medications that turned into chemotherapy. The development of specific care for blood cancers and the emergence of AIDS and patient activism. He discusses the surgery for breast cancer. It was thought that the more radical the surgery the better the outcomes. We now know that lumpectomies have an excellent outcome. But, women before me had a radical removal of breast, chest tissue, lymph nodes and sometimes ribs. The lesson learned is that breast cancer is very curable now and all those men and women, the patients who suffered, gave us the answers and cancer care has moved on.
The onslaught of chemotherapies changed the face of cancer, and the 1970's served us well. In 1986 the first outcomes of cancer care were measured. Tobacco emerged as an addiction and soon lung cancer was a leading cause of death. Presidential Commissions ensued, politics entered the world of cancer, the war against cancer and the war against smoking. The Pap smear was developed, and prevention came to the fore. The two sides of cancer, the researchers and the physicians at the bedside, who often thought never the twain shall meet, recognized the importance of research to bedside.
The story of the boy 'Jimmy' from New Sweden, Maine, became the face of childhood cancer. The Jimmy Fund, a Boston Red Sox charity in Boston, is still going strong today. 'Jimmy' opened the door to the public for the need for money and research, and care for those with cancer. We follow Dr Mukherjee with one of his first patients, Carla, from her diagnosis through her treatment. He has given a face to cancer. We all know someone with cancer, those who survived and those who did not. Cancer prevention is now the wave of the future.
"Cancer is and may always be part of the burden we carry with us," says Dr Mukherjee. He has now written a "biography of cancer" for us, those without special medical knowledge. However, he does go astray in some discussions such as genetics. I have an excellent medical background, and found I was floundering at times. As I discovered,and Dr. Mukherjee agrees, our patients are our heroes. They/we withstand the horrors of cancer, and the horrific, sometimes deadly treatments. The stories of his patients make us weep, and the complex decision making about their care make him the most caring of physicians.
The 'quest for the cure' is the basis of all science and research, and Dr Mukherjee has written a superb tome in language that we can all attempt to understand. The biography of Cancer. Cancer may always be with us,Dr Mukherjee hopes that we outwit this devil and survive.
Highly Recommended. prisrob 11-13-10
Jimmy Fund of Dana-Farber Cancer Institute, The (MA) (Images of America)Early Detection: Women, Cancer, and Awareness Campaigns in the Twentieth-Century United States
