The Forever Fix: Gene Therapy and the Boy Who Saved It and over one million other books are available for Amazon Kindle. Learn more

The Forever Fix: Gene Therapy and the Boy Who Saved It 1st Edition

38 customer reviews
ISBN-13: 978-0312681906
ISBN-10: 0312681909
Why is ISBN important?
ISBN
This bar-code number lets you verify that you're getting exactly the right version or edition of a book. The 13-digit and 10-digit formats both work.
Scan an ISBN with your phone
Use the Amazon App to scan ISBNs and compare prices.
Have one to sell? Sell on Amazon
Buy used
$8.99
Buy new
$25.99
Amazon Price New from Used from
Kindle
"Please retry"
Hardcover, March 13, 2012
"Please retry"
$25.99
$6.96 $0.01
More Buying Choices
25 New from $6.96 28 Used from $0.01 2 Collectible from $9.96
Free Two-Day Shipping for College Students with Amazon Student Free%20Two-Day%20Shipping%20for%20College%20Students%20with%20Amazon%20Student


InterDesign Brand Store Awareness Rent Textbooks
$25.99 FREE Shipping on orders over $35. Only 8 left in stock. Ships from and sold by Amazon.com. Gift-wrap available.

Frequently Bought Together

The Forever Fix: Gene Therapy and the Boy Who Saved It + Campbell Biology, Books a la Carte Plus MasteringBiology -- Access Card Package (9th Edition)
Price for both: $191.57

Buy the selected items together

Editorial Reviews

Review

In this impressive, meticulously researched study of the exciting new developments in gene therapy, geneticist and journalist Lewis (Human Genetics) looks closely at the history of setbacks plaguing the treatment of rare genetic diseases as well as recent breakthroughs...Yet with each success, as Lewis recounts in this rigorous, energetic work, possibilities in treating HIV infection and dozens of other diseases might be around the next corner. (Publisher's Weekly (starred review))

A fascinating account of groundbreaking science and the people who make it possible. (Kirkus)

Ricki Lewis gives us the inspiring story of gene therapy as told through Corey's eyes--literally. Her book delves into the challenges modern medicine faces--both in its bitter disappointments and great successes--but it goes much deeper than that. With empathy and grace, Lewis shows us the unimaginable strength of parents with sick children and the untiring devotion of the physicians who work to find 'the forever fix' to save them. But best of all Lewis gives us a story of profound hope. (Molly Caldwell Crosby, author of The American Plague: The Untold Story of Yellow Fever, the Epidemic that Shaped Our History and Asleep: The Forgotten Epidemic that Remains One of Medicine's Greatest Mysteries)

The Forever Fix is a wonderful story told by one of our most gifted science and medical writers. In the tradition of Siddhartha Mukherjee's The Emperor of All Maladies, Ricki Lewis explains complex biological processes in extremely understandable ways, ultimately providing crucial insights into the modeling of disease and illustrating how gene therapy can treat and even potentially cure the most challenging of our health conditions. (Dennis A. Steindler, Ph.D., former Executive Director of the McKnight Brain Institute, University of Florida)

Ricki Lewis has written a remarkable book that vividly captures the breathtaking highs and devastating lows of gene therapy over the past decade while giving ample voice to all sides -- the brave patient volunteers, their parents and physicians. The Forever Fix is required reading as we dare to dream of curing a host of genetic diseases. (Kevin Davies, Founding editor of Nature Genetics; author of The $1,000 Genome and Cracking the Genome)

In 'The Forever Fix,' Ms. Lewis chronicles gene therapy's climb toward the Peak of Inflated Expectations over the course of the 1990s. A geneticist and the author of a widely used textbook, she demonstrates a mastery of the history. (The Wall Street Journal)

An engaging and accessible look at gene therapy. (Times Union)

Medical writer Ricki Lewis interweaves science, the history of medical trial and error, and human stories … from the death in 1999 of teenager Jesse Gelsinger, from a reaction to gene therapy intended to combat his liver disease, to radical successes in some children with adenosine deaminase deficiency. (Nature)

Lewis adeptly traverses the highs and lows of gene therapy and explores its past, present, and future through the tales of those who've tested its validity. (The Scientist)

About the Author

RICKI LEWIS is a Ph.D. geneticist, journalist, professor and genetic counselor. The author of one of the most widely used college textbooks in the field (Human Genetics: Concepts and Applications, now in its 10th edition), she has also written hundreds of popular pieces on science and other topics for trade and specialized magazines, including Nature, Discover, and The Scientist.

NO_CONTENT_IN_FEATURE


Best Books of the Month
Best Books of the Month
Want to know our Editors' picks for the best books of the month? Browse Best Books of the Month, featuring our favorite new books in more than a dozen categories.

Product Details

  • Hardcover: 336 pages
  • Publisher: St. Martin's Press; 1 edition (March 13, 2012)
  • Language: English
  • ISBN-10: 0312681909
  • ISBN-13: 978-0312681906
  • Product Dimensions: 5.5 x 0.9 x 8.5 inches
  • Shipping Weight: 14.4 ounces (View shipping rates and policies)
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (38 customer reviews)
  • Amazon Best Sellers Rank: #628,772 in Books (See Top 100 in Books)

More About the Author

On a bright September Sunday in 2008, 8-year-old Corey Haas walked up the pathway to the Philadelphia zoo holding his parents' hands, looked up, and screamed. It was the first time he'd seen the sun.

Four days earlier, Corey had undergone gene therapy for hereditary blindness at Children's Hospital of Philadelphia. An eye surgeon had gently placed billions of viruses bearing healing genes just beneath the rods and cones of Corey's left eye. Now, at the zoo, seeing the sun hurt.

Corey's suddenly restored vision marked a renaissance for gene therapy, a biotechnology sadly sidelined nine years earlier when an 18-year-old died in a similar experiment in the same city, also in just four days.

The Forever Fix tells the riveting saga of gene therapy: how it works, the science behind it, how young patients have been helped and harmed, and how researchers learned from each trial to inch one step closer to its immense promise, the promise of a "forever fix" - a cure that, by correcting a problem at its genetic roots, doesn't need further treatment.

Corey's inspiring true story unfolds against the backdrop of other children receiving gene therapy since the field was born in 1990, and those looking ahead to it in the coming months. The treatments pioneered on their rare diseases will reverberate to many more common illnesses. The compelling voices of the children, families, researchers, and physicians at the forefront of this biotechnology relate the ups and downs that have led to its recent success, and looming acceptance. And no one has told these intertwining stories - until now.

The Forever Fix, dedicated to the children of gene therapy, is a celebration of science, medicine, parent activism, and most important of all, hope.

RICKI LEWIS is a Ph.D. geneticist, journalist, professor and genetic counselor. The author of one of the most widely used college textbooks in the field (Human Genetics: Concepts and Applications, now in it's 10th edition), she has also written hundreds of articles for trade and specialized magazines, including Nature, Discover, and The Scientist. She is a hospice volunteer and frequent public speaker. Ricki lives near Schenectady, NY, and as much as possible in Martha's Vineyard.

Follow Ricki Lewis on Twitter (@rickilewis), on her blog Genetic Linkage (www.rickilewis.com), and at https/www.facebook.com/rickilewisauthor.




Customer Reviews

Most Helpful Customer Reviews

13 of 14 people found the following review helpful By Ilyce on March 16, 2012
Format: Hardcover
The Forever Fix is one of the most moving books I have had the pleasure to read. This might come as s surprise given the high technical nature of the subject matter. The story of gene therapy is not just a historical recitation of the efforts of dedicated scientists who have advanced research, embedded in this story are the individual stories of the families and their brave children who battle the effects of their disorders every day.

As Max's mom (featured in her book), I am grateful for the opportunity to share our story and bring to light both the daily challenges of raising a child with a rare genetic disorder as well as our journey in seeking a medical therapy to help my precious son.

Without these brave families and their children, none of the advances in gene therapy would be possible. I am forever grateful to Ricki Lewis for bringing attention to both the science and the lives these medical advancements have touched ~Ilyce Randell
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
6 of 6 people found the following review helpful By Robert Derham on March 20, 2012
Format: Hardcover
Lewis does an excellent job of unraveling the history of gene therapy layer by layer. Where others center around the success of science, Lewis masterfully interweaves the bitter reality of failure and the footmarks of success and helps her reader understand how failure was necessary to improve the science to ensure modern day's use of gene therapy was more successful.

If gene therapy incites thoughts of fear and thus reservation about whether it should be allowed, Lewis sides with her readers' reservations and takes them face to face with the failure of medicine throughout time and how it affected the patient, their family and the treating physicians. However, her brilliance emerges in how she doesn't make excuses for the failure, rather, she suggests it as a form of medical evolution to her readers. Why?

Because medicine is not a perfect science, Lewis might argue and she poignantly conveys that medical history is riddled with disastrous beginnings that eventually laid the groundwork for medical techniques that society now readily embraces as "routine."

But she never lets her reader forget that there are people who bravely died so that we can now benefit from routine procedures.

Many scientific techniques are quite abstract because they involve things that society cannot touch and often do not understand. Before the lay person has a chance to be turned off by the detailed science, Lewis masterfully puts an abstract treatment into the palms of her readers by educating them step by step about the science behind gene therapy.

"Touch its potential, hold its infancy and feel its power over life and death," Lewis seemingly pleads with her reader.
Read more ›
1 Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
4 of 4 people found the following review helpful By David Lemberg on March 29, 2012
Format: Hardcover
In "The Forever Fix", Dr. Ricki Lewis tells a terrific story. Years ago, at the dawn of genomics, bioinformatics and "personalized medicine", gene therapy was lauded as the next big thing. But serious problems occurred and clinical trials were effectively banned. More recently, gene therapy has picked up steam and several breakthroughs have been achieved. Dr. Lewis brings a deep knowledge of science and the scientific method, as well as the broad skill set of the experienced writer, to her description of how gene therapy restored a young boy's sight. This is a wonderful tale of human interest and a compelling overview of the field of gene therapy. Highly recommended for a general audience as well as researchers and physicians.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
3 of 3 people found the following review helpful By Nigel Hey on June 27, 2012
Format: Hardcover
If, like me, you grew up believing that scientists can't write, here's the proof of how wrong one can be. This is a science book so skilfully constructed that it reads like a novel - except that it is a true story about an undeniably important subject, the promise of gene therapy.

Here is an author whose writing skill is such that she can take on a difficult subject and blend it with real-life, factual information so deftly that you're likely to forget you're reading a book about cutting-edge science. Words like adrenoleukodystrophy will not disturb you. Instead, you will very quickly realize that this is a book about vulnerable young people, their families and their carers. Importantly, it is also about the people on research teams and hospital staffs who believe that with time gene therapy can improve and save the lives of more youngsters in the future.

It is not necessarily a pretty story. Tragedy is built into the stories of the youngsters who did not respond to certain types of gene therapy and did not survive. Success comes in the stories of people like Corey Haas, the central character of this story, who underwent gene therapy for hereditary blindness, and his family. Corey's sight gradually returned, a success story that gave hope to the millions who suffer from "glitches' that prevent genes from doing their job. Science knows enough about genes these days that Corey's problem was traced to a gene that normally would use vitamin A to send visual signals to his brain. The challenge was to undo the genetic problem so that Corey's descent into blindness would cease and his sight would return. Incredibly it worked.

Author Ricki Lewis, a geneticist by training, explains with engaging clarity how this revolution is coming about.
Read more ›
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again

Most Recent Customer Reviews

Set up an Amazon Giveaway

Amazon Giveaway allows you to run promotional giveaways in order to create buzz, reward your audience, and attract new followers and customers. Learn more
The Forever Fix: Gene Therapy and the Boy Who Saved It
This item: The Forever Fix: Gene Therapy and the Boy Who Saved It
Price: $25.99
Ships from and sold by Amazon.com

What Other Items Do Customers Buy After Viewing This Item?

Want to discover more products? Check out this page to see more: newborn barney