From the Back Cover
How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, and structure? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?
The Academic Press FactsBook series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "A growing series of excellent manuals' by Molecular Medicine Today
, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties and biological activity. Meticulously researched and compiled by experts in the field, keeping abreast of developments has never been so easy!
With The Gene Knockout FactsBook
, the series brings you from the molecule in isolation to its function in the whole animal. This two volume work contains information on the phenotypes of 600 mice in which a single gene has been inactivated by targeted mutation. Mice with mutations affecting aspects of immunology, development, neurobiology, metabolism, apoptosis and cancer (amongst others) furnish valuable insights into the functions of these genes.
Entries provide information on:
* general description of the protein and its function
* gene symbol and database accession number
* knockout construct
* mouse phenotype
* key references
About the Author
Tak W. Mak is the Director of the Campbell Family Institute for Breast Cancer Research in the Princess Margaret Hospital, Toronto, Canada, and a University Professor in the Departments of Medical Biophysics and Immunology, University of Toronto. He was trained at the University of Wisconsin in Madison, the University of Alberta, and the Ontario Cancer Institute. He gained worldwide prominence in 1984 as the leader of the team that first cloned the genes of the human T cell antigen receptor. His group went on to create a series of genetically altered mice that have proved critical to understanding intracellular programs governing the development and function of the immune system, and to dissecting signal transduction cascades in various cell survival and apoptotic pathways. His current research remains centered on mechanisms of immune recognition/regulation, malignant cell survival/death, inflammation in autoimmunity and cancer, and metabolic adaptation in tumor cells. Dr. Mak has published over 700 papers and holds many patents. He has been granted honorary doctoral degrees from universities in North America and Europe, is an Officer of the Orders of Canada and Ontario, and has been elected a Foreign Associate of the National Academy of Sciences (U.S.), a Fellow of the Royal Society of London (U.K.), and a Fellow of the AACR Academy. Dr. Mak has won international recognition as the recipient of the Emil von Behring Prize, the King Faisal International Prize for Medicine, the Gairdner Foundation International Award, the Sloan Prize of the General Motors Cancer Foundation, the Novartis Prize in Immunology, the Robert Noble Prize, the Killam Prize, the Stacie Prize, the McLaughlin Medal, and the Paul Ehrlich and Ludwig Darmstaedter Prize.