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The Organic Chemistry of Biological Pathways [Hardcover]

John McMurry , Begley Tadhg
4.4 out of 5 stars  See all reviews (5 customer reviews)

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Book Description

February 1, 2005 0974707716 978-0974707716 1st Edition

Intended for advanced undergraduates and graduate students in all areas of biochemistry, The Organic Chemistry of Biological Pathways provides an accurate treatment of the major biochemical pathways from the perspective of mechanistic organic chemistry.


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Editorial Reviews

Review

"The book's greatest strength is its emphasis on the conceptual unity of organic chemistry and biochemistry. The chemical structures are presented with great care and accompanied by lucid explanations." —Charles Clapp, Bucknell University
 



"This textbook elegantly portrays the complementary nature of chemistry and biology. By describing biological processes in detailed chemical terms, the authors have provided a resource that provides an unparalleled look into the fascinating and emerging field of chemical biology." —Hung-wen Liu, University of Texas



"This textbook satisfies a major need in chemistry curricula, bridging the gap between introductory organic chemistry and biochemistry/biology. It is the first book written for students that presents biological transformations from the perspective of organic mechanism. The book significantly augments modern biochemistry curricula and may catalyze a resurgence of interest in biological mechanism." —Carolyn R. Bertozzi, University of California, Berkeley

About the Author

John E. McMurry received his B.A. from Harvard University and his Ph.D. at Columbia University. Dr. McMurry is a Fellow of the American Association for the Advancement of Science, and an Alfred P. Sloan Research Foundation Fellow. He has received several awards, which include the National Institutes of Health Career Development Award, the Alexander von Humboldt Senior Scientist Award, and the Max Planck Research Award. In addition to The Organic Chemistry of Biological Pathways, he is also the author of Organic Chemistry, Fundamentals of Organic Chemistry, and Chemistry (with Robert Fay).

Tadhg P. Begley received his B.Sc. from National University of Ireland and his Ph.D. at the California Institute of Technology. Dr. Begley is the recipient of many awards, including the Merck Faculty Development Award and the Camille and Henry Dreyfus Teacher-Scholar Award. His research group uses the principles and techniques of organic chemistry to study complex organic transformations found in vitamin biosynthetic pathways. In addition to The Organic Chemistry of Biological Pathways, Dr. Begley has edited Cofactor Biosynthesis: A Mechanistic Perspective.


Product Details

  • Hardcover: 512 pages
  • Publisher: Roberts and Company Publishers; 1st Edition edition (February 1, 2005)
  • Language: English
  • ISBN-10: 0974707716
  • ISBN-13: 978-0974707716
  • Product Dimensions: 9.5 x 7.6 x 1.4 inches
  • Shipping Weight: 3 pounds (View shipping rates and policies)
  • Average Customer Review: 4.4 out of 5 stars  See all reviews (5 customer reviews)
  • Amazon Best Sellers Rank: #132,382 in Books (See Top 100 in Books)

More About the Author

John E. McMurry received his B.A. from Harvard University and his Ph.D. at Columbia University. He is a Fellow of the American Association for the Advancement of Science, and an Alfred P. Sloan Research Foundation Fellow. He has received several awards, which include the National Institutes of Health Career Development Award, the Alexander von Humboldt Senior Scientist Award, and the Max Planck Research Award. In addition to ORGANIC CHEMISTRY, he is also the author or coauthor of ORGANIC CHEMISTRY, A BIOLOGICAL APPROACH, FUNDAMENTALS OF ORGANIC CHEMISTRY, THE ORGANIC CHEMISTRY OF BIOLOGICAL PATHWAYS, CHEMISTRY, and FUNDAMENTALS OF GENERAL, ORGANIC, AND BIOLOGICAL CHEMISTRY.

Customer Reviews

4.4 out of 5 stars
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Most Helpful Customer Reviews
3 of 3 people found the following review helpful
5.0 out of 5 stars Great book September 18, 2010
By Meagan
Format:Hardcover|Verified Purchase
This is a very easy to read book. If you have already taken organic chemistry it may be a bit of a review but it does apply the information to biological pathways. If you have not already taken organic chemistry, it is a great book to learn it. I think that it is easier, yet just as comprehensive as other textbooks out there, but it skips over things that are more useful in physical organic chemistry (energy equations and things like that). We are using it in our biochemistry class and it's a great review that gets to the point.
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5 of 6 people found the following review helpful
Format:Hardcover
This book is simply great. The scholar and very clear presentation by the authors make the subject of each chapter almost self-explanatory. The first two chapters introduce the organic reactions which are relevant in biosynthesis, stereochemistry of biological molecules and the major classes of primary metabolites. In the following chapters the authors discuss, with care and in detail, the biosynthesis of every class of primary metabolite, showing mechanisms for every single reaction. The last chapter on biosynthesis presents examples of some natural products biosynthesis (classical examples). Unfortunately, no example on the biosynthesis of phenylpropanoid derivatives is included. However, even though, the book is worth of purchase for students and teachers interested in the mechanistic aspects of primary and secondary metabolites biosynthesis.
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4 of 5 people found the following review helpful
3.0 out of 5 stars Useful, but somewhat disappointing December 1, 2012
Format:Hardcover|Verified Purchase
When I opened the book for the first time, my immediate reaction was "Wow, there's not much text, is there?" The page is fairly small to begin with, the font is fairly large, the line spacing and margins are generous, and there are a lot of figures. I realized after a while that this wasn't an especially fair criticism, though. Because the purpose of the text is primarily to show mechanisms of important metabolic reactions, most of the information can be conveyed through chemical structures. In fact, a significant chunk of the text is devoted to saying (paraphrased), "well, it's extremely difficult to determine exact mechanisms, so the precise path that this reaction follows is uncertain. The figure shows the most commonly proposed mechanism, but another possibility is that..." The alternative is most often explained in words but sometimes gets its own figure.

The book is very descriptive, offering mostly "what" and "how" rather than "why." Arguably, there's nothing inherently wrong with that, especially because the preface essentially says directly that that's the purpose of the book. But it does mean that the book is quite limited, and isn't very useful on its own. You would need a fully fleshed-out course to extract much value from it, and unfortunately, I know from firsthand experience that a well-designed course is far from a given. Our lectures and exams basically just asked us to regurgitate the mechanisms from the text, which was not useful or enjoyable. That seems to be the danger: a lazy lecturer told to use this textbook to teach a course will produce a worthless class from which the students will take away almost nothing of lasting value.

All that aside, there are still some quibbles with the book.
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5 of 7 people found the following review helpful
5.0 out of 5 stars Clear-cut explanatons August 21, 2005
Format:Hardcover
This book is most suitable as an organic chemistry text for biological pathway and would be valuable for undergraduate students. Each of mechanisms are well illustrated with colorful charts. To my reglet, there is no description on the nitrogen fixation. Nevertheless I recommend it as one of the valuable study-aid book.
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4.0 out of 5 stars Great for BCHM special topics course! January 20, 2014
Format:Hardcover|Verified Purchase
Great book for a specialized metabolic pathway class! Excellent addition to your students' biochemistry text. Clear, concise and well explained. A salute to the authors and Roberts publishing.
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