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The Art of Process Chemistry Hardcover – December 6, 2010

ISBN-13: 978-3527324705 ISBN-10: 3527324704 Edition: 1st

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Editorial Reviews

Review

"The book will be of great value to students looking to move into a career in process research; the enthusiasm and commitment of the authors comes over in the text, and the attention to detail and emphasis on mechanistic evaluation is a lesson to all. Academics will find much material that can be used in teaching . . . so in conclusion, this is an outstanding book which discusses the art of process research and developing process understanding." (Organic Process, Research & Development Journal, 17 December 2010)

From the Back Cover

The refinement of a chemical process to the point where it becomes both cost and time efficient can be seen as "art." In a competitive environment where pharmaceutical companies are under ever increasing pressure to bring new drugs more quickly to the market, ways need to be found to provide bulk supplies of drug candidates as quickly as possible and to design manufacturing routes, which are robust, economical and environmentally firendly. This monograph is divided into 9 chapters, each one concentrating on a single class of drug candidates of chemistry development and describing the routes explored and the optimizations made to each drug candidate, inluding the discovery of applicable new chemistry and the elucidation of reaction mechanism.

From the contents:

  • Efairenz®, a Non-Nucleoside Reverse Transciptase Inhibitor (NNRTI), and a Previous Structurally Related Development Candidate
  • CCR5 Receptor Antagonist
  • 5α-Reductase Inhibitors – The Finsteride Story
  • Rizatriptan (Maxalt®): A 5-HT1D Receptor Agonist
  • SERM: Selective Estrogen Receptor Modulator
  • HIV Integrase Inhibitor: Raltegravir
  • Cyclopentane-Based NK1 Receptor Antagonist
  • Glucokinase Activator
  • CB1R Inverse Agonist – Taranabant

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