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The Viral Storm: The Dawn of a New Pandemic Age [Paperback]

Nathan Wolfe
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Editorial Reviews

Review

"By turns terrifying and comforting, The Viral Storm is a clear, riveting account of the threat of undiscovered viruses" ---Mary Roach, author of Stiff --This text refers to the Audio CD edition.

About the Author

NATHAN WOLFE is the Lorry I. Lokey Visiting Professor in Human Biology at Stanford University and the founder and CEO of Global Viral Forecasting, an independent research institute devoted to early detection and control of epidemics. He holds degrees from Stanford and Harvard and has been published in or profiled by Nature, Science, The New York Times, The New Yorker, The Economist, Wired, Discover, Scientific American, NPR, Popular Science, Seed, and Forbes. In 2011 he was named one of Time magazine's 100 Most Influential People in the World. He lives in San Francisco.

Excerpt. © Reprinted by permission. All rights reserved.

Introduction

The village of Pang Thruk in the Kanchanaburi province of Thailand is like many in this part of the world—humid, lush, and spilling over with sounds of wildlife. Located in the west of the country near the border of Burma, Pang Thruk is home to about three thousand people whose livelihoods depend on the sugar and rice they grow. In December 2003, it was also home to Kaptan Boonmanuch, a six-year-old boy who would be among the first people to die of a brand-new human virus.

Kaptan loved riding his bicycle, climbing trees, and playing with his plastic toy Dalmatian that pulled three puppies in tiny brown wagons as it barked mechanically. Kaptan also enjoyed helping his family on the farm.

Nearly every family in Pang Thruk kept egg-laying chickens; some also kept roosters for cock fighting. Kaptan's aunt and uncle lived just down the road on their open-air farm of around three hundred chickens. Each winter in the village a few chickens would die from suspected infections or colds, but in December 2003 chicken deaths increased dramatically. That winter, as on many farms in this region, the chickens in Kaptan's uncle's farm suffered from severe diarrhea, strange behavior, and weakness. All of them either died naturally or were culled as a result of their illness—and Kaptan helped with the dead. A day or two before the New Year, according to reports, the boy carried one of the sick squawking chickens home. That walk home would have lasted no more than a few minutes.

A few days later Kaptan grew feverish. A clinic in the village diagnosed him with a cold, but after three days without improvement, his father, Chamnan, a rice farmer who worked part time as a driver, took him to a public hospital. X-rays revealed that the six-year-old had pneumonia, and he was kept in the hospital for observation. A few days more and Kaptan's fever spiked to a dangerous 105 degrees. His father paid the equivalent of thirty-six dollars for an ambulance to speed him to better care at Siriraj Hospital in Bangkok, more than an hour's drive away.

Upon arrival, Kaptan presented with shortness of breath and fever. Tests revealed that both lungs were affected with severe pneumonia, and the boy was transferred to the pediatric intensive care unit and put on a ventilator. A series of bacterial cultures tested negative, showing that the infection was likely caused by a virus. More detailed testing using a molecular technique called the polymerase chain reaction, or PCR, revealed that Kaptan was likely infected with an atypical type of influenza—perhaps one not yet seen (or seen widely) in humans.

After eleven days of illness, the boy's fever finally began to cool off. However, despite intensive care, his respiratory distress worsened. Just before midnight on January 25, physicians took Kaptan off the respirator. His lungs drowning in fluids, he became Thailand's first known death from H5N1, which would soon become known around the world as "bird flu."

As sad as Kaptan's death was—and the reports go on to describe the boy's funeral and the family's mourning in tragic detail—the reality is that children in the developing world die from diseases like this all the time. And infectious diseases, which scientists in the 1960s predicted would be eliminated in short order, remain some of the most important killers today. But when it comes to global risk, all deaths are not equal. Most deaths from infectious diseases are localized events that, while dire for the victims and their families, present limited risk to the planet as a whole. But some, like Kaptan's, signal a potentially world-altering event: the first human infection by an animal virus that may wipe out millions, or hundreds of millions, of people throughout the planet—permanently changing the face of humanity.

The main objective of my work is to hunt down these events—the first moments at the birth of a new pandemic—and then work to understand and stop them before they reach a global stage. Because pandemics almost always begin with the transmission of an animal microbe to a human, it's work that takes me all around the globe—from rain forest hunting camps of central Africa to wild animal markets of east Asia. But it also takes me to cutting-edge laboratories at the US Centers for Disease Control and Prevention (CDC) and disease outbreak control centers at the World Health Organization (WHO). Tracking down these potentially devastating bugs has led me to study how, where, and why pandemics are born. I work to create systems that can accurately detect pandemics early, determine their likely importance, and, with any luck, crush those that have the potential to devastate us.

As I've lectured on this work around the world and taught undergraduates in my virology seminar at Stanford University, it's hard to ignore a growing general interest in these topics. Everyone recognizes the raw power that pandemics have to sweep through human populations and seemingly kill indiscriminately. Yet, given the importance of these events, large questions remain remarkably opaque:

How do pandemics start?

Why are we now plagued with so many pandemics?

What can we do to prevent pandemics in the future?

This book is my attempt to answer these questions—an effort to assemble the pieces of the pandemic puzzle.

Part I, "Gathering Clouds," introduces our main character, the microbe, [1] and delves into the history of our relationships with these organisms. It explores the vast world of microbes, putting those that threaten us in their proper perspective. It details some of the most significant events in the evolution of humans and our ancestors and works to develop the often-spotty historical data into a set of hypotheses on how the events influenced our interactions with microbes.

Part II, "The Tempest," examines how contemporary human populations have grown so exquisitely susceptible to pandemics and what the future years will hold for pandemic diseases. Part III, "The Forecast," describes the fascinating new world of pandemic prevention and introduces a new crop of scientists eager to help create a virtual global immune system that will stop pandemics before they become planetary nightmares. Along the way, we will journey to remote hunting villages in central Africa, investigate malaria in wild orangutans in Borneo, learn how cutting-edge genetic sequencing tools will change the way that we discover completely novel viruses, and see how Silicon Valley companies may forever transform the way that we conduct surveillance aimed at finding the next major outbreak.

At this point you may be asking yourself how someone ends up devoting his career to the study of plagues. Is it a desire to save the world? Or perhaps it's the scientific thrill of discovering completely unknown, invisible beings with the potential to wipe out large swaths of humanity. Maybe it's the desire to understand in detail one part of humans' intricate ecology. Or it's an urge to explore the exotic locations on Earth where these novel viruses often appear. But while my life is now consumed with trying to understand and stop pandemics, that's not how it's always been. My work with microbes actually started as a minor footnote to a study I wanted to conduct among wild chimpanzees in central Africa.

As a young child, I acquired what would become a lifelong interest in apes when I watched a National Geographic documentary explaining how humans are more closely related to apes than we are to monkeys. A family tree with humans and apes as siblings (and monkeys as distant cousins) was entirely inconsistent with my memories of seeing these creatures locked up together in the "monkey house" at the Detroit Zoo. We humans were outside the cages, and the rest of them were inside. The idea that apes and humans were closely related certainly struck a chord with me. According to my father, I spent some days after the documentary playing the part: walking around the house on all fours, trying to communicate without language, and otherwise working to bring out my inner ape.

My fascination with apes evolved from a childish curiosity to an intellectual interest in what our closest relatives had to tell us about ourselves. What began as a broad interest in apes as animals became a more specific interest in chimpanzees and their less acknowledged brethren, the bonobos—the two ape species that share our own particular branch of the tree of life. How did the years of separation since our last common ancestor with these two kindred ape species shape our minds, our bodies, and our worlds? What features remained the same in all of us?

Along with the intellectual interest, I had a growing desire to see these apes living in their natural environment. This desire required tracking them down in the rain forests of central Africa to see for myself what they were really like. So when choosing among doctoral programs, I settled on one at Harvard where I would work with Richard Wrangham and Marc Hauser, two prominent primatologists. I would spend many months during my first year of doctoral work arguing why they should let me study the troops of wild chimpanzees that Wrangham had worked with for years in the Kibale Forest in southwest Uganda.

I proposed a study to document self-medicating behavior of the Kibale chimpanzees. The idea that these animals consumed plants with specific medicinal chemicals as a way of fighting against their own infectious diseases was still just an hypothesis at the time, and an intriguing one. I'd explored this idea the previous year while studying at Oxford and working on an exhibit about animal self-medication at the Oxford University Museum of Natural History.

The Oxford University Museum is a magnificent nineteenth-century building constructed in the architectural style of a Gothic cathedral but with massive iron supports mimicking the skeleton of a mammal, emphasizing that it was a church of natural history rather than religion. It houses unique collections, i... --This text refers to an out of print or unavailable edition of this title.

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