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Gene Therapy for Neurological Disorders & Brain Tumors (Contemporary Neuroscience)
 
 
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Gene Therapy for Neurological Disorders & Brain Tumors (Contemporary Neuroscience) [Hardcover]

E. Antonio Chiocca (Editor), Xandra O. Breakefield (Editor)

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Book Description

0896035077 978-0896035072 April 15, 1998 1st
Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.


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Editorial Reviews

Review

"a very interesting book. . .all 'gene therapy laboratories' and 'neuo-gene therapy laboratories' will be able to derive much intellectual nourishment and stimulation, practical tips, and predictions about the future from this truly challenging volume."-Human Genetics

From the Back Cover

Drs. Chiocca and Breakefield bring together in Gene Therapy for Neurological Disorders and Brain Tumors many of the leading gene therapy researchers and clinicians to capture the breadth of the field-from basic vector technology to current and future clinical applications. The authoritative contributions provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorders, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Gene Therapy for Neurological Disorders and Brain Tumors illuminates the rapidly developing applications of gene transfer technologies to the treatment of a wide range of neurological disorders and brain tumors. Readers will learn the current delivery methods for transgenes, will learn the characteristics of the transgene delivery vectors, and come to more fully understand gene therapies for both neuro-oncologic and neurologic disorders.

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Inside This Book (learn more)
First Sentence:
Transfer of therapeutic genes into diseased cells using retroviral vectors is a promising approach for the treatment of certain, virtually incurable diseases. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
nonglial cells, chromaffin cell survival, rat brain tumor models, virus early promoter, human glucocerebrosidase gene, transvascular delivery, gene therapy for neurological disorders, stereotactic inoculation, human glioma cell lines, bradykinin infusion, packaging cell lines, amplicon vectors, human glioma cells, primary intracranial tumors, basal promoter region, experimental brain tumors, helper virus genome, brain tumor therapy, human glioblastoma cells, main tumor mass, intracerebral tumors, simplex virus mutants, brain tumor cells, astrocytic tumors, rat glioma model
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Gene Ther, Brain Res, New York, Nature Genet, Cancer Inst, Cold Spring Harbor, Humana Press Inc, Nature Med, Acta Neurochir, Acta Neuropathol, New Biol, Cell Biol, San Diego, Genes Dev, Trends Neurosci, Blood Flow Metab, Dranoff Fig, Fields Virology, Opinion Neurobiol, United States, Brain Pathol, Cancer Treatment Rep, Cell Mol, Nucleic Acids Res
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