Three-Dimensional Electron Microscopy of Macromolecular Assemblies (Hardcover)

by Joachim Frank (Author)
Key Phrases: alignment methods, specimen preparation methods, total interimage variance, Two-Dimensional Averaging Techniques, Elsevier Science, Three-Dimensional Reconstruction (more...)

Editorial Reviews

Product Description
Cryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest biomedical research interest. This book, the successor to an earlier work published in 1996 with Academic Press, is a natural companion work to our forthcoming book on electron crystallography by Robert Glaeser, with contributions by six others, including Frank. A growing number of workers will employ CryoEM for structural studies in their own research, and a large proportion of biomedical researchers will have a growing interest in understanding what the capabilities and limits of this approach are. --This text refers to the Hardcover edition.

About the Author
Joachim Frank is at Howard Hughes Medical Institute. --This text refers to the Hardcover edition.

Product Details

• Hardcover: 342 pages
• Publisher: Academic Press; 1 edition (January 1996)
• Language: English
• ISBN-10: 0122650409
• ISBN-13: 978-0122650406
• Product Dimensions: 9.5 x 6.5 x 0.8 inches
• Shipping Weight: 1.4 pounds
• Average Customer Review: 5.0 out of 5 stars See all reviews (1 customer review)
• Amazon.com Sales Rank: #2,671,934 in Books (See Bestsellers in Books)

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Customer Reviews

Most Helpful Customer Reviews

3 of 3 people found the following review helpful:

5.0 out of 5 stars Crash Course in Single Particle Microscopy, February 20, 2002

By	Edmund Paley "Lutheran Biochemist" - See all my reviews

This concise and easy to read book is essentialy a crash course in single particle reconstruction by electron microscopy. It isn't exactly a how-to manual, more an overview of how the whole process works. Thus, it is useful not only to someone who wants to learn how to do this, but also to those who might be interested in deciding if this technique would be useful to them. And actually, the whole topic is sufficiently cool that I would recommend the book even to people who know they will never use this technique, just because its fun to read about it. The book is clearly written and doesn't assume alot of prior knowledge. A basic undergrad education in math would be enough to handle the equations.