Toxicological Evaluation of Certain Veterinary Drug Residues in Food (Who Food Additives) [Paperback]

Book Description

Series: Who Food Additives | Publication Date: January 2002

This volume contains monographs prepared by the sixtieth meeting of the Joint FAO/WHO Expert Committee on Food Additives. The toxicological monographs in this volume summarize the safety data on the veterinary drug residues that were evaluated by the Committee, which included two antimicrobial agents (neomycin and flumequine), one insecticide (trichlorfon) and one production aid (carbadox). The data summarized in these monographs served as the basis for the evaluations performed by the Committee. This book contains information that is useful to those who produce and use veterinary drugs and food additives and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories, and universities.

--This text refers to an alternate Paperback edition.

Product Details

• Paperback: 91 pages
• Publisher: World Health Organization (January 2002)
• Language: English
• ISBN-10: 924166049X
• ISBN-13: 978-9241660495
• Product Dimensions: 8.9 x 5.9 x 0.3 inches
• Shipping Weight: 7.8 ounces
• Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)

Customer Reviews

Most Helpful Customer Reviews

5.0 out of 5 stars An excellent book, January 11, 2005

By 

Professor Anil Aggrawal "anil" (india) - See all my reviews

This review is from: Toxicological Evaluation of Certain Veterinary Drug Residues in Food (Who Food Additives) (Paperback)

Animals are god gifted social creatures whose health is coequally important as that of human beings. They not only serve as an important component of our sources of nutrition but also role models for testing of drugs for the safety evaluation. Thus, it is essential to establish a scientific basis of the veterinary drugs for its use in animals and also its associated risk to them as well as humans.


IPCS deals with one of these stated objectives assessing the risk to health from exposure to a particular chemical entity, persistent reviewing of the data, promotion of chemical safety and technical assistance for sound management of this.

This book presents the toxicological monographs prepared by 58th meeting of joint FAO/WHO, this included two antihelminths -doramectin & tiabendazoles and antimicrobial agent -Cefuroxime. The monographs were prepared on the basis of working papers reviewed by the committee.

The antihelminth agent Doramectin was evaluated earlier in 45th meeting and an additional safety factor was assigned to it. In this series it was rechecked for the additional risk factor. Its toxicity was linked to expression of genetic variation in expression of P Glycoproteins. This drug is indicated for the treatment of onchocerciasis in Africa & Latin America, no neurotoxicity was observed in humans and was found to be safe as a single dose in pregnancy. On these findings this additional risk factor was removed.

The other congener discussed is tiabendazole which is a broad spectrum antihelminth and is also used as a fungicide in plant protection. On analysis of the recent linked data on toxicology, this drug raised concern for safety. Hence it was decided to define and establish a acute reference dose (acute RfD )for this drug. The committee reviewed toxic effects of this drug on various system for acute toxicity and developmental toxicity which were considered relevant for establishing acute RfD.
...The information [in this book] is useful for the animal handlers in animal house, manufactures of veterinary drugs, food authorities dealing with contamination of food residues, industrial testing laboratories, toxicological labs and food regulatories. ...

Cefuroxime, a broad spectrum cephalosporin with antibacterial activity used for the treatment of mastitis in cattle was assessed. This was evaluated for the first time. A complete biological information on the pharmacokinetic aspect, biotransformation and toxicity studies in various species including man was submitted and assessed. It Was proposed that a significant transformation occurs only in cattle and not in other laboratory animals or man. Milk residues were analysed and it proved no threat on safety.

This is a small book limited only to two drugs but gives a whole lot of information on them. At the same time it prattles that the assessment of veterinary drugs is an important concealed horizon which should be looked upon.

This information is useful for the animal handlers in animal house, manufactures of veterinary drugs, food authorities dealing with contamination of food residues, industrial testing laboratories, toxicological labs and food regulatories.
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