Tumour Angiogenesis [Paperback]

Roy Bicknell (Editor), Claire E. Lewis (Editor), Napoleone Ferrara (Editor)

Book Description

Publication Date: September 18, 1997 | ISBN-10: 0198549377 | ISBN-13: 978-0198549376 | Edition: 1

This is the first comprehensive book to cover all areas of a rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases, extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis, including vascular endothelial growth factor, the basic fibroblast growth factor family, transforming growth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumor microvessel density and the therapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

Editorial Reviews

Review

`'...a timely book about an area that is rapidly gaining in popularity...this contribution will be most useful for the researchers in the field, in particular for scientists new to angiogenesis who will benefit from this extensive and thorough introduction. The book will also function well as a dictionary for people working in related areas...this is an extensive, well written and comprehensive book.'' Trends in Cell Biology (Vol.8) October 1998.

`'This is an interesting book...'' Cellular and Molecular Biology, June vol.44/No.4, 1998.

About the Author

Dr Roy Bicknell, Imperial Cancer Research Fund, University of Oxford, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxon OX3 9DU, Tel [phone], Fax [phone], email: [e-mail]; Dr C E Lewis, Senior Lecturer, Department of Pathology, University of Sheffield Medical School, Royal Hallamshire Hospital, Sheffield S10 2JF, Tel [phone], Fax [phone] Dr N Ferrara, Department of Cardiovascular Research, Grenentech Inc, South San Francisco, California, USA,

Product Details

• Paperback: 408 pages
• Publisher: Oxford University Press, USA; 1 edition (September 18, 1997)
• Language: English
• ISBN-10: 0198549377
• ISBN-13: 978-0198549376
• Product Dimensions: 9.7 x 7.5 x 1 inches
• Shipping Weight: 2.3 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #5,145,558 in Books (See Top 100 in Books)