Ubiquitin and Disease [Hardcover]

J. Pallares-Trujillo (Author), Josep M., FJ Lopez-Soriano, Argiles (Author)

Book Description

ISBN-10: 1570595453 | ISBN-13: 978-1570595455 | Publication Date: December 1, 1998

The book deals with the understanding of the molecular basis of diseases where defects in ubiquitin gene expression and/or synthesis are involved. Among these, Alzheimer's and other neurodegenerative diseases, muscle dystrophies, cancer, muscle wasting and autoimmune diseases.

The importance of the ubiquitin-dependent proteolysis is also studied in aging and a special emphasis is put in understanding the regulation of this ATP-dependent proteolytic system in order to design future therapeutic strategies.

19 figures, 14 tables

TOC

Part I Introduction Chapter 1 Proteolysis: A Pleyade of Systems Chapter 2 The Ubiquitin System and Proteolysis Part II Ubiquitin and Disease Chapter 3 Alzheimer and other Neurodegenerative Diseases Chapter 4 Cancer Chapter 5 Muscle Wasting and Dystrophies Chapter 6 Other Pathological States Chapter 7 Aging Chapter 8 The Role of other Proteolytic Systems in Disease Chapter 9 Cell Injury and Cell Death: Apoptosis Part III Regulation and Therapeutic Implications Chapter 10 The Regulation of the UB System Chapter 11 The Design of Therapeutic Strategies

Editorial Reviews

Review

This book is unique due to its discussion of the involvement of the ubiquitin-dependent proteolyitc system in different types of pathological diseases. -- Publisher Comments

About the Author

Josep M. Argiles obtained his Doctorate from the University of Barcelona n 1981. He then became a Lecturer in biochemistry and carried out postdoctoral work on acetone metabolism in mammals. In 1987 he undertook further postdoctoral training in the Laboratory of Molecular Biology at at the National Institute of Health, Bethesda, Maryland. In 1988 he became interested in the role of cytokines in the modulation of the host response and went to the Metabolic Research Laboratory, Radcliffe Infirmary, Oxford, UK to work on the metabolic effects of tumor necrosis factor and interluekin-1. At present he is Professor of Biochemistry and Molecular Biology at the Faculty of Biology, University of Barcelona, being the leader of a research group interested in the molecular mechanisms involved in protein degradation.

Francisco J. Lopez-Soriano obtained his Doctorate from the University of Barcelona in 1987 investigating the role of amino acids in brown adipose tissue thermogenesis. Later, he undertook postdoctoral research in he Metabolic Research Laboratory, Radcliffe Infirmary, Oxford, UK, working on different aspects of cytokines during the perinatal period. In 1988 he was promoted to Professor of Biochemistry and Molecular Biology in the University of Barcelona where he at present investigating the role of cytokines in muscle wasting and its relation with cachexia. He is also in charge of Biochemistry and Molecular Biology of Cancer in the studies leading to a biochemistry degree.

Javier Pallares-Trujillo obtained his academic degree in 1983 from the Faculty of Pharmacy at the University of Barcelona. He then undertook his Doctorate at the Consejo Superior de Investigaciones Cientificas in Barcelona working on the role of protein kinase C and lipid metabolism in multi-drug resistance. At present is a formal scientific advisor of Dr. Argiles group at the Department of Biochemistry University of Barcelona.

Product Details

• Hardcover: 174 pages
• Publisher: Landes Bioscience (December 1, 1998)
• Language: English
• ISBN-10: 1570595453
• ISBN-13: 978-1570595455
• Product Dimensions: 9 x 6 x 0.7 inches
• Shipping Weight: 1 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #7,122,554 in Books (See Top 100 in Books)