Recent studies have revealed that that uveal melanoma and cutaneous melanoma are remarkably different diseases. Uveal Melanoma: A Model for Exploring Fundamental Cancer Cell Biology provides insights into some of these differences and summarizes recent developments regarding the basic research on biology and metastasis of uveal melanoma. It is a compendium of 20 chapters written by an international collection of authors who are currently involved with uveal melanoma research. They explore current research and thinking on the pathobiology of and expansion of treatment options for, this type of melanoma. Illustrations include characterization of genomic uveal melanoma cell lines.
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4 of 4 people found the following review helpful:
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Biology of a Cure?,
By See A Cure "Eye Cancer Nonprofit" (Boston, MA) - See all my reviews
This review is from: Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology (Hardcover)
Why do some small and unremarkable primary uveal melanomas metastasize while larger, more invasive eye tumors do not?
What factors cause an existing choroidal nevus to transform into a choroidal melanoma? And how are those factors different from or similar to the ones that cause uveal melanomas to arise de novo (new)? How on earth is it possible that the rates of incidence (the number of people diagnosed) and mortality (number of people dying) for uveal melanoma remain eerily unchanged for decades despite diagnosing and treatment advances? Just what is uveal melanoma? More importantly, how do we successfully treat this rare and puzzling cancer? This book does not answer any of these questions. So far, much of the research on uveal melanoma chromosomes, molecules and proteins has only confirmed long-standing clinical observations that tumor pigmentation, diameter, blood vessel morphology, cell type, race, and eye color influences its prevalence, progression and prognosis. In other words, all this cellular research has merely affirmed on a genetic level what was already known on a clinical level. Real progress will only be achieved when this genetic research is translated into improved patient outcomes - progress which appears decades away from reality. If, as one of the authors argues, that uveal melanoma is "an excellent model for the study of cancer biology in general," than a more multi-disciplinary and-faceted approach is warranted. That kind of support is not only going to come from the lab but also from the larger community of medical professionals and their patients. This was a fascinating book which ironically proves that research alone will not lead us to see a cure.
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