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Visualization of Nucleic Acids [Hardcover]

Gerard Morel (Author)

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Book Description

ISBN-10: 0849347815 | ISBN-13: 978-0849347818 | Publication Date: March 30, 1995 | Edition: 1

This book presents a review of the principle approaches for visualizing DNA and RNA. Using scanning tunneling and atomic force microscopes, the three-dimensional image of the surface of nucleic acids can be seen at atomic-scale resolutions. Spreading methods provide useful details on structural features of isolated molecules, but the major constituent of living matter is water, and the cryomicroscope makes it possible to look at DNA in its aqueous environment. Genes can be detected simultaneously in situ in chromosomes using fluorescent probes, and also at the electron microscopic level. In cells, nucleic acids are localized and quantified by dyes; electron microscopy is used with cytochemical, immunocytological, nuclease, and in situ hybridization methods. The main potential applications for pathological studies are shown with particular aspects such as viral nucleic acids and in situ PCR.

#outer_postBodyPS { display: none; } #psGradient { display: none; } #psPlaceHolder { display: none; } #psExpand { display: none; } This book presents a review of the principle approaches for visualizing DNA and RNA. Using scanning tunneling and atomic force microscopes, the three-dimensional image of the surface of nucleic acids can be seen at atomic-scale resolutions. Spreading methods provide useful details on structural features of isolated molecules, but the major constituent of living matter is water, and the cryomicroscope makes it possible to look at DNA in its aqueous environment. Genes can be detected simultaneously in situ in chromosomes using fluorescent probes, and also at the electron microscopic level. In cells, nucleic acids are localized and quantified by dyes; electron microscopy is used with cytochemical, immunocytological, nuclease, and in situ hybridization methods. The main potential applications for pathological studies are shown with particular aspects such as viral nucleic acids and in situ PCR.

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Product Details

Hardcover: 384 pages
Publisher: CRC Press; 1 edition (March 30, 1995)
Language: English
ISBN-10: 0849347815
ISBN-13: 978-0849347818
Product Dimensions: 10.2 x 7.3 x 0.8 inches
Shipping Weight: 2.3 pounds (View shipping rates and policies)
Amazon Best Sellers Rank: #8,110,548 in Books (See Top 100 in Books)

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Inside This Book (learn more)

First Sentence:
With the discovery of the microscope by Antonie van Leuwenhoek, the observation of live tissues became possible. Read the first page

Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
osmium ammine complex, ammine reaction, antinucleic acid antibodies, confocal spectral imaging, fibrillogranular network, orange acridin, loosening procedure, thallium ethylate, viral nucleoids, bare grid method, mild loosening, herpes simplex genomes, replicative foci, progeny viral genomes, viral minichromosomes, parental viral genomes, lowicryl sections, electron opaque marker, cellular chromatin, denaturation mapping, viral region, pyrimidic bases, viral probe, phosphoric groups, host chromatin

Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cell Biol, Nucleic Acids Res, New York, Cell Res, Academic Press, Cell Sci, Boca Raton, Press Inc, Cold Spring Harbor, Practical Approach, Methods Enzymol, Cancer Res, Boehringer Mannheim, Adenine Press, Kidney Int, Protocol Cells, Raven Press, Stain Technol, Van Nostrand Reinhold, Detection of Newly Synthesized, Detection Technique, John Wiley, Microscopic Electronique, None Intercalation, Oxford University Press

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Citations (learn more)

This book cites 42 books:

Hybridization Techniques for Electron Microscopy by Gerard Morel on 5 pages
Practical Methods in Electron Microscopy by A.M. Glauert on page 90, page 132, and page 323
Comprehensive Virology (Physics of Atoms and Molecules) by Fraenkel on page 322, and page 323
Cryotechniques in Biological Electron Microscopy by R.A. Steinbrecht on page 65, and page 66
Principles and Techniques of Electron Microscopy by M. A. Hayat on page 50, and page 54

See all 42 books this book cites

5 books cite this book:

In Situ Detection of DNA Damage: Methods and Protocols (Methods in Molecular Biology, Vol 203) (Methods in Molecular Biology) by Vladimir V. Didenko on page 130
Flow Cytometry Applications in Cell Culture by Mohamed Al-Rubeai on page 192
Triple Helix Forming Oligonucleotides (Perspectives in Antisense Science) by Claude Malvy on page 60
Histological and Histochemical Methods: Theory and Practice by J. A. Kiernan in Back Matter
Synthetic DNA Delivery Systems (Biotechnology Intelligence Unit) by Dan Luo on page 43

Books on Related Topics (learn more)

Human Polyomaviruses by Kamel Khalili

Discusses:

In Situ Hybridization by D. G. Wilkinson

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Live Cell Imaging by Robert D. Goldman

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Immuno Gold Electron Microscopy in Virus Diagnosis and Research by Alexander D. Hyatt

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