I don't know. The information I received with my IMac specified the speed of, and type of chips, how they were to be installed, etc. All I had to do was decide the configuration, 2x4GB or 2x8GB, and follow the instructions. Hope this helps!
Just follow the Advisor tool for selection process...I can't say if "no problems" will occur..! Crucial Memory Advisor™ Tool Use our Advisor tool to find guaranteed-compatible upgrades specific to your computer model: http://www.crucial.com/