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Wondergenes: Genetic Enhancement and the Future of Society
 
 
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Wondergenes: Genetic Enhancement and the Future of Society [Hardcover]

Maxwell J. Mehlman (Author)

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Book Description

Medical Ethics September 16, 2003

Wondergenes not only imagines a future world in which genetic enhancement is the norm, but asserts that this future has already begun. Genetically engineered substances are already in use by athletes, in vitro fertilization already provides the primitive means by which parents can "select" an embryo, and the ability to create new forms of genetically engineered human beings is not far off. What happens when gene therapy becomes gene enhancement? Who will benefit and who might be left behind? What are the costs to our values and beliefs, and to the future of our society? To answer these questions, Maxwell J. Mehlman provides an overview of the scientific advances that have led to the present state of genetic enhancement and explains how these advances will be used in the future to redefine what we think of as a normal human being. He explores the ethical dilemmas already facing researchers and medical practitioners, and the dilemmas we will all be expected to face. In his forecast of the dangers inherent in this technology, he is particularly concerned with the emergence of a "genobility" made up of those able to afford increasingly expensive enhancement.

Wondergenes is a serious, accessible introduction to the social and personal implications of genetic engineering. Mehlman weighs the social and economic costs of the many proposals to regulate or limit genetic engineering and provides six concrete policy recommendations—from professional licensing to a ban on germ-line enhancement—that propose to make the future of genetic enhancement more equitable and safe.


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Editorial Reviews

From The New England Journal of Medicine

Wondergenes is an engaging and readable overview of the potential benefits and harmful effects of genetic enhancement and of what might be done to limit the harm. Although the book raises no major new issues, it brings together, in a vivid and understandable way, probable social consequences that will need consideration as this field of genetic science moves ahead. The three main sections of the book unfold in a logical sequence. The first chapters describe the "revolutions" in knowledge in the fields of forensic genetics, genetic information, gene therapy, and behavioral genetics, and then the definition of genetic enhancement is approached. First, Mehlman discusses the difficulty of distinguishing between therapy and enhancement and asks what makes an enhancement "genetic." His response is very broad. It includes not only the insertion of genes into human DNA but also such situations as the implantation of male embryos that have been selected by genetic testing, as part of in vitro fertilization, or the use of drugs whose manufacture is made possible by knowledge gained from genetics (for example, human growth hormone or erythropoietin). The succeeding chapters, which make up the second part of the book, lay out the dilemmas for and challenges to society that are raised by the rapidly growing capabilities of the field of genetics. Mehlman outlines what he sees as the inevitable destruction of democracy and social harmony if genetic enhancement (which is expensive) turns out to be possible, advantageous, and desired by many people yet its use is not controlled. He effectively makes the case for the view that, even if no one were interested in conducting research on genetic enhancement, advances in genetic medicine targeted at diseases would pave the way toward such developments and that economic motivation in a market economy will ensure that entrepreneurs will work to develop applications of enhancement technology that promise a profit. These chapters describe a future in which genetic alterations in some people will lead to diverging populations and to a world in which the resultant genetic inequalities will undermine society. Mehlman considers it possible that eventually the "genobility" may be so genetically different that these intelligent beings will no longer be considered human. The last part of the book moves toward potential solutions and possible mechanisms to prevent this dystopian future. Mehlman considers the possibility of providing genetic enhancements to all who wish them, but he believes that this would be prohibitively expensive. He then considers banning genetic enhancements and examines the institutions in the United States (such as the Food and Drug Administration and the Drug Enforcement Administration) that might deal with this possibility. The lucid, easy-to-follow description of the current regulatory framework and of the roles of the various agencies and the gaps between them does not inspire confidence that the instruments yet exist to ensure that genetic enhancements will be managed to society's benefit. The difficulty and complexity of regulating this field are convincingly described, and the practical difficulty of stopping the further development and use of genetic enhancement -- not only the impediments within the United States but also what might happen if these activities "go offshore" -- is clearly laid out. It is plain that limiting the uses of genetic enhancement would require a major overhaul of the current regulatory framework. Upholding a ban on some or all of the uses of genetic enhancement would depend on whether the dangers to the state's interest appeared clear. Speculation about future harm that seems removed would not be enough, but Mehlman shows vividly that by the time such harm might become clear, a ban might be too late. Many of the scenarios he describes are predicated on the assumption that genetic enhancement will be effective in the foreseeable future. However, human traits that are widely seen as desirable or advantageous (such as intelligence, attractiveness, and strength) are determined in a complex manner, and whether it will indeed prove possible to affect such traits in a reliable and safe way in coming decades is open to question. Nevertheless, scientific advances are sometimes surprising, and this book shows that if genetic enhancement does become possible, humanity will face a problem of major proportions. It will then have been useful to have thought about and explored some of the social consequences and possible responses, as this book does. If genetic enhancement does not become possible, this book will nevertheless have been an interesting one to read. Patricia A. Baird, M.D.
Copyright © 2004 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.

Review

"Wondergenes is Maxwell Mehlman's wake—up call to a world that hasn't quite figured out that our genetic future is here. A whole generation of children, senior citizens, and the middle aged are drinking, injecting and pumping chemicals into their bodies to get 'an edge' in every aspect of life. Is that good? Is that fair to the rest of the world—or even the rest of the soccer team? Mehlman is brilliant, and this is the most sophisticated discussion of enhancement ever written, covering the ethical, legal and personal issues that are already on our doorstep. This book will be on the shelf of every policymaker, clergyperson, and businessnessperson who wants to 'get ahead' on the subject of 'getting ahead.'" —Glenn McGee, Editor, The American Journal of Bioethics

(Glenn McGee, Editor, The American Journal of Bioethics )

"Mehlman deftly explores this powerfully seductive and socially destabilizing biotechnology, and authoritatively suggests legal steps we humans must take to regulate it if we are to have any real chance to garner its benefits and avoid its species—wide destructive potential. —George J. Annas, author of The Rights of Patients and c" —founder of Global Lawyers and Physicians



"Wondergenes is a spirited and lively guide to the promises and perils of genetic enhancement. Well—grounded in the science, [the book] poses the central ethical questions posed by enhancement, explains the legal context, and offers intriguing suggestions for law and public policy." —Thomas H. Murray, President, The Hastings Center

(Thomas H. Murray, President, The Hastings Center )

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Inside This Book (learn more)
First Sentence:
"Nearly two centuries ago, in this room, on this floor, Thomas Jefferson and a trusted aide spread out a magnificent map-a map Jefferson had long prayed he would get to see in his lifetime. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
enhancement lottery, somatic enhancements, hancement purposes, germ line enhancement, line genetic enhancement, reproductive enhancement, netic enhancements, corrected genes, enhancement research, germ line engineering, embryo selection, enhancement drugs, gene therapy experiments, enhancement products, germ line gene therapy, genetic illness, enhancement use, enhanced individuals, enhancement services
Key Phrases - Capitalized Phrases (CAPs): (learn more)
United States, Supreme Court, Human Genome Project, Jesse Gelsinger, Federal Food, White House, Cosmetic Act, James Watson, John Rawls, World War, Advisory Committee, African Americans, Cold Spring Harbor, Controlled Substances Act, Disabilities Act, Francis Collins, Martin Cline, President Clinton, Ronald Dworkin, Sir Frances Drake, Ted Turner, World Trade Center
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