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The "rest cure" was prescribed most commonly to women who had recently given birth. Suffering from what we now know is post-partem depression (caused by hormonal fluctuations of seratonin that result from the female body adjusting to not having a fetus to delivering hormones to), women were locked up and kept from seeing their newly born children.
Gilman's book, therefore, is not only an American literary classic, but it also provides insight into America's social history; a history which will not be forgotten as long as people continue to carefully read this psychologically wrought story.