That is one of my main uses. I have a laptop and attach a second monitor so I can work on both monitors side by side. the only thing I now see sometimes is a delay on the mouse movement, which I'm hoping they will fix on the next software update.
I use it with a 17" HP Laptop - the laptop screen is monitor one and I have a 23" Samsung monitor connected to the Plugable via an HDMI adapter as monitor two. The Plugable itself uses "DisplayLink" to support the one "extra" monitor. I hope that answered your question. If you are going for a total of 3 monitors this is not your solution.