Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization (Hardcover)

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Key Phrases: solubility methods, permeability methods, pharmaceutical aspects, Journal of Medicinal Chemistry, Drug Discovery Today, Journal of Pharmaceutical Sciences (more...)

Editorial Reviews

Review

JOURNAL OF MEDICINAL CHEMISTRY, OCTOBER 2008: "The authors do an excellent job of providing insight into the background of the many factors that influence drug-like properties...[This] easy-to-read text is...an excellent addition to the library of practicing medicinal chemists and of graduate students in the pharmaceutical sciences. It provides a wealth of information for a reasonable price."--Thomas E. Prisinzano, Dept. of Medicinal Chemistry, University of Kansas, KS, USA

DOODY'S, SEPTEMBER 2008: "This is a valuable reference for any scientist who works as part of a drug discovery team and especially those who are involved in ADME to toxicity optimization [.] The authors have done a nice job of presenting this information in a concise, readable format."--Thomas Pazdernik, University of Kansas Medical Center, KS, USA

"[Recently] I bought your excellent book, and I want to congratulate you and thank you for injecting life into the science of ADMET, lifting the subject to 'bestseller,' enjoyable reading material. It is the best book that I have come across that makes a great job of fostering collaborative interactions between ADMET and Medicinal Chemistry scientists in advancing strategies of drug discovery."--Dr. Collen Masimirembwa, Chief Scientific Officer, AiBST

"I am very impressed...[The book] is destined to become an authoritative text on the whole topic area of drug-like molecules and ADME screening. The chapters are well written and include sufficient detail and references so that the reader can make use of the information effectively. The book could be used in a graduate-level course for medicinal chemists or DMPK scientists. The book would also be very helpful for scientists working in one area of DMPK who wish to become DMPK project managers and need to increase their understanding of other areas of DMPK that are outside of their own specific expertise function. The chapter on pharmacokinetics provides a very good overview of the topic. This book is well worth the purchase price." --Walter Korfmacher, NJ, USA

Book Description

Provides drug discovery scientists and students with a practical understanding of property fundamentals, effects, structure-property relationships, and structure modification strategies that can be applied to improving drug leads.

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Product Details

• Hardcover: 552 pages
• Publisher: Academic Press; 1 edition (February 19, 2008)
• Language: English
• ISBN-10: 0123695201
• ISBN-13: 978-0123695208
• Product Dimensions: 10.3 x 7.3 x 1.4 inches
• Shipping Weight: 3 pounds (View shipping rates and policies)
• Average Customer Review: 4.5 out of 5 stars  See all reviews (4 customer reviews)
• Amazon.com Sales Rank: #61,864 in Books (See Bestsellers in Books)

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Customer Reviews

Most Helpful Customer Reviews

4 of 5 people found the following review helpful:

5.0 out of 5 stars A very impressive book!, February 23, 2008

By	Walter Korfmacher "MS expert" (New Jersey, USA) - See all my reviews (REAL NAME)

I have spent some of the last two days reading this book and I am very impressed with it. It is destined to become an authoritative text on the whole topic area of drug-like molecules and ADME screening. The chapters are well written and include sufficient detail and references so that the reader can make use of the information effectively. The book could be used in a graduate-level course for medicinal chemists or DMPK scientists.
The book would also be very helpful for scientists working in one area of DMPK who wish to become DMPK project managers and need to increase their understanding of other areas of DMPK that are outside of their own specific expetise function. The chapter on pharmacokinetics was well written and provides a very good overview of the topic. Overall, I can state that this book is well worth the purchase price.

5.0 out of 5 stars Very, very helpful, August 1, 2009

By	Big Chucko "Chucky" (Massachusetts, Ma) - See all my reviews

This book contains a wealth of information concerning a number of topics of special interest to medicinal chemists in the pharmaceutical or animal science business. On many occasions I have sought and found useful information in this book - it serves as a very good primary source for basic information related to many aspects of preclinical drug discovery. This book fills a great void and should find its way onto the desk of any medicinal chemist who wants to learn more about understanding and manipulating the pharmaceutical properties of their compounds. Highly recommended!!

4.0 out of 5 stars The medicinal chemistry book you were looking for., March 28, 2009

By	Carlos Mateos Gutierrez - See all my reviews (REAL NAME)

It is very nice overview of the practical topics for the practicing medicinal chemist.
For the just arrived synthetic chemist, it represents a way of looking not so puzzled in project meetings when interacting with experienced collegues.
For senior drug-hunters, it is a guide to check for clear understanding of drug properties in the selection and optimization of new leads. Emphasis is placed on the methods for measuring properties using high throughput, diagnostic and in-depth methods.
In a nutshell, a very useful learning material for scientists engaged in drug discovery and a reference for regular use.