Pcp Phencyclidine Historical and Current Perspectives (Hardcover)

~ Edward F. Domino (Editor)

Product Details

• Hardcover: 537 pages
• Publisher: NPP Books (June 1981)
• Language: English
• ISBN-10: 0916182037
• ISBN-13: 978-0916182038
• Product Dimensions: 9.5 x 6.5 x 1.5 inches
• Shipping Weight: 1.9 pounds
• Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
• Amazon.com Sales Rank: #4,081,452 in Books (See Bestsellers in Books)

Customer Reviews

Most Helpful Customer Reviews

5.0 out of 5 stars About This Book, September 14, 2008

By	Theseus "theseus" (US of A) - See all my reviews

From the Preface:

"The time has come to document the history of PCP -- its synthesis, early pharmacology, clinical use and disappointment. No one associated with the early development of PCP would have, in their wildest imagination, predicted that this drug would be abused to the extent it has been in the Unites Sates in the past few years."

This book "is the outgrowth of a workshop held in San Juan, Puerto Rico, December 13, 1979 under the auspices of the American College of Neuropsychopharmacology. However, a number of additional investigators have submitted material that was not part of that meeting and this is also incorporated in this book."

TABLE OF CONTENTS
- Historical Development of PCP
- Neuropharmacology
- History of the Developement of Cataleptoid Anesthetics of the Phencyclidine Type
- Phencyclidine Revisited
- Structure Activity Relationships of Phencyclidine Derivatives
- Synthesis, Conformation, and Physical Properties
- Receptor Sites for Phencyclclidine in Mammalian Brain and Peripheral Organs
- Identification and Characterization of [3H] Phencyclidine Binding to Specific Brain Receptor Sites
- Integrated Studies
- Biotransformation
- Synaptosomal Dopamine Synthesis
- Effects on Behavior
- Tolerance and Dependence
- First Dose Behavioral Tolerance
- Phencyclidine and Naloxone
- Interdisciplinary Studies
- Abnormal Mental States Induced by Phencyclidine as a Model of Schizophrenia
- Chronic Abuse
- Diagnostic Problems
- A Clinical Approach to the Treatment of PCP Abuse
- Bases for the Treatment of PCP Intoxication
- Future Directions