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Editorial Reviews
From Publishers Weekly
Since the ImClone scandal first broke, most of the media's attention has focused on CEO Sam Waksal's insider trading and the charges filed against Martha Stewart, a close friend and investor in the pharmaceutical company. Prud'homme, who first reported on ImClone for Vanity Fair, reminds readers of the bigger story, the one that set the financial hijinx in motion: ImClone's failed attempt to bring a potentially groundbreaking cancer medication, Erbitux, to market. This story tells of scientists like John Mendelsohn, who led the research into C225, the antibody at the heart of Erbitux, and patients like Shannon Kellum, a 28-year-old woman diagnosed with colon cancer for whom the medication was a "miracle drug" that added a few years to her life. She was one of the rare lucky ones; Prud'homme's reporting is especially strong when he delves into the seemingly haphazard way in which ImClone distributed C225 for "compassionate use" during the clinical testing period. The FDA's rejection of ImClone's "scientifically incomplete" test data was the immediate motivation for Waksal's crimes, but Prud'homme's portrayal suggests it was completely in character for the reckless social-climbing executive, described by acquaintances as a "pathological liar" who cared more about making money than about curing cancer. Prud'homme ends his compelling account with Waksal's sentencing, and even though he'll inevitably have to update the paperback to wrap up coverage of the Martha Stewart trial, it's well worth reading the book now to appreciate what's really at stake in ImClone's downfall.
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.
From Booklist
As this is written, jurors are being selected for lifestyle-marketing entrepreneur Martha Stewart's trial on charges of insider trading of her shares in the small drug-development company ImClone. Stewart was a friend to ImClone CEO Sam Waksal, and he is already in prison for doing as she allegedly did on a much larger scale. As large as that scale was, Waksal's ill-gotten gains didn't begin to match his personal indebtedness. He loved living large, knowing the stars, and being part of the in crowd. The son of Holocaust survivors, a medical researcher who shifted from the lab to a front office, and charming as the day is long, Waksal had waited long enough to cash in when, in the mid-1990s, he seized on a promising cancer drug as ImClone's and his winning ticket. He cut a deal with pharmaceutical giant Bristol-Myers Squibb to produce the substance and launched the tests necessary to get the drug FDA approval. But he was living so high that he felt compelled to cut corners and rush the payoff. When the FDA balked--as it should have--his personal house of cards collapsed. The drug and ImClone didn't fall with him, which is fortunate mostly because, as Prud'homme shows in the most interesting pages of his long, exemplarily written report, the stuff remains very promising as a specific against tumors. Ray Olson
Copyright © American Library Association. All rights reserved
See all Editorial Reviews
Since the ImClone scandal first broke, most of the media's attention has focused on CEO Sam Waksal's insider trading and the charges filed against Martha Stewart, a close friend and investor in the pharmaceutical company. Prud'homme, who first reported on ImClone for Vanity Fair, reminds readers of the bigger story, the one that set the financial hijinx in motion: ImClone's failed attempt to bring a potentially groundbreaking cancer medication, Erbitux, to market. This story tells of scientists like John Mendelsohn, who led the research into C225, the antibody at the heart of Erbitux, and patients like Shannon Kellum, a 28-year-old woman diagnosed with colon cancer for whom the medication was a "miracle drug" that added a few years to her life. She was one of the rare lucky ones; Prud'homme's reporting is especially strong when he delves into the seemingly haphazard way in which ImClone distributed C225 for "compassionate use" during the clinical testing period. The FDA's rejection of ImClone's "scientifically incomplete" test data was the immediate motivation for Waksal's crimes, but Prud'homme's portrayal suggests it was completely in character for the reckless social-climbing executive, described by acquaintances as a "pathological liar" who cared more about making money than about curing cancer. Prud'homme ends his compelling account with Waksal's sentencing, and even though he'll inevitably have to update the paperback to wrap up coverage of the Martha Stewart trial, it's well worth reading the book now to appreciate what's really at stake in ImClone's downfall.
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.
From Booklist
As this is written, jurors are being selected for lifestyle-marketing entrepreneur Martha Stewart's trial on charges of insider trading of her shares in the small drug-development company ImClone. Stewart was a friend to ImClone CEO Sam Waksal, and he is already in prison for doing as she allegedly did on a much larger scale. As large as that scale was, Waksal's ill-gotten gains didn't begin to match his personal indebtedness. He loved living large, knowing the stars, and being part of the in crowd. The son of Holocaust survivors, a medical researcher who shifted from the lab to a front office, and charming as the day is long, Waksal had waited long enough to cash in when, in the mid-1990s, he seized on a promising cancer drug as ImClone's and his winning ticket. He cut a deal with pharmaceutical giant Bristol-Myers Squibb to produce the substance and launched the tests necessary to get the drug FDA approval. But he was living so high that he felt compelled to cut corners and rush the payoff. When the FDA balked--as it should have--his personal house of cards collapsed. The drug and ImClone didn't fall with him, which is fortunate mostly because, as Prud'homme shows in the most interesting pages of his long, exemplarily written report, the stuff remains very promising as a specific against tumors. Ray Olson
Copyright © American Library Association. All rights reserved
See all Editorial Reviews
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Inside This Book Citations: This book cites 13 books Explore: Citations | Books on Related Topics | Concordance | Text Stats Key Phrases - SIPs: physician advisory board, oncology drugs, colorectal cancer patients, pharma companies, colon cancer patients (more) Key Phrases - CAPs: Martha Stewart, New York, Sam Waksal, Wall Street, Time Warner (more) Browse Sample Pages: Front Cover | Copyright | Table of Contents | Excerpt | Index | Back Cover | Surprise Me! |
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