Review
"A valuable reference text for practitioners needing accurate information on drug-induced agranulocytosis and aplastic anemia." --The Annals of Pharmacology
"Provides a systematic exposition of the study methodology and results, organized in a detailed . . . style. . . . the most comprehensive reference available. . . . deserves a place in medical libraries of universities, research institutes, government agencies, and pharmaceutical companies." --Harry A. Guess, American Journal of Epidemiology
"Provides a systematic exposition of the study methodology and results, organized in a detailed . . . style. . . . the most comprehensive reference available. . . . deserves a place in medical libraries of universities, research institutes, government agencies, and pharmaceutical companies." --Harry A. Guess, American Journal of Epidemiology
Product Description
Agranulocytosis and aplastic anemia figure prominently among certain serious diseases which can be precipitated by drugs. Several hundred different agents with substantially different chemical and pharmacological properties have been implicated, although the evidence incriminating specific drugs has been largely anecdotal. This book describes the findings of a rigorous and comprehensive epidemiological investigation designed to provide reliable quantitative data on the drug etiology of agranulocytosis and aplastic anemia. This investigation was a large-scale, population based , case-control study. Its objectives were to identify those drugs associated with agranulocytosis and aplastic anemia, and to estimate incidence rates attributable to specific drugs. In both conceptual and practical terms, this study has broken new ground, by providing the most extensive documentation to date concerning the drug etiology and incidence of the two dyscrasias.
