Product Description
High Performance Liquid Chromatography in Biotechnology Edited by William S. Hancock
This important book details the broad range of analytical techniques that have made HPLC so successful in the separation and quantitation of product variants-a procedure essential to quality assurance of protein pharmaceuticals. Outlined are the major chromatographic techniques-reversed phase, ion exchange, affinity and hydrophobic interaction chromatography-as well as their role in specific separations. Also described are the methods required for a quality control program. Reflecting the heightened concern for product integrity since the advent of new protein pharmaceuticals by recombinant-DNA techniques, this critical reference will enhance the libraries of analytical chemists, biochemists, and chemical engineers working with HPLC. 1990 (0-471-82584-0) 624 pp.
The publisher, John Wiley & Sons
Details major developments in the practical applications of High Performance Liquid Chromatography. An essential resource for chromatographers who wish to improve their techniques in HPLC research, this collection of articles by specialists in the field presents both a broad overview of recent developments as well as more detailed knowledge in areas of chromatography involving biotechnology. Different analytical techniques required for the detection of variants are described, as is the transformation of an analytical into a preparative separation. Mass spectroscopy and related technologies used for structural characterization are discussed. Together, the contributions provide a complete picture of this exciting and rapidly moving field.
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