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24 of 26 people found the following review helpful:
3.0 out of 5 stars
"Honest Jim's" Version of a Major Scientific Event, January 27, 2004
+++++
In this book (first published in 1968), "Honest Jim" (as a scientist friend called him) or Dr. James Dewey Watson has explained his "version of how the structure of DNA was discovered" and "this account represents the way [he] saw things then, in [the fall of] 1951 [to the spring of] 1953." (The discovery was announced in April 1953.) That is, he has "attempted to re-create [his] first impressions of the relevant events and personalities" that he encountered along the way to making the discovery. Thus, understand this is not a book of historical facts.
Also, because of the personal nature of this book Watson states that "many of the comments [that he makes] may seem one-sided and unfair, but this is often the case in the incomplete and hurried way in which human beings decide to like or dislike a new idea or [a new] acquaintance."
This book revolves around five main people:
(1) Dr. Francis Crick (1916 to 2004) of the Cavendish Laboratory in Cambridge, England
(2) Dr. James Watson (born 1928) also of the Cavendish Laboratory
(3) Dr. Rosalind Franklin (1920 to 1958) of King's College, a division of the University of London
(4) Dr. Maurice Wilkins (1916 to 2004) also of King's College
(5) Dr. Linus Pauling (1901 to 1994) of the California Institute of Technology.
However, along the way the reader meets many other people, both scientists and non-scientists.
As Watson explains, the above five people are in a "race" to discover DNA's structure. However, I got the impression that neither Franklin nor Wilkins knew they were in a race. By the end of the race, Watson was "one of the winners" who shared the Nobel Prize in 1962 with Crick and Wilkins.
According to the official Nobel Prize internet site, Watson, Crick, and Wilkins won a shared Nobel Prize in physiology "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material."
This 29-chapter (with epilogue) book is a fast read (but only if you gloss over the science parts). As Watson proceeds in this story, you'll find that he is quite sociable and takes us to such places as pubs, restaurants, and "smashing" parties.
As you read this book, you'll find that there is considerable tension between Watson and Franklin (who was an expert in X-ray diffraction crystallography) as well as between Wilkins and Franklin.
For me, this book imparts four major things:
(1) THE THRILL OF DISCOVERY. That is, this book effectively conveys, especially in the latter chapters, the struggle to find the correct answer. With each chapter, the anticipation mounts toward the final climax: the discovery of the double helical structure of DNA.
(2) HOW SCIENCE IS DONE. For example, both Watson & Crick and Pauling used molecular models while Franklin & Wilkins used X-ray crystallography. However, all science is not done as it is conveyed in this book. As Watson states, "styles of scientific research vary almost as much as human personalities."
(3) THE QUESTION OF ETHICS IN SCIENCE. For example, Wilkins told Watson secretly that Franklin "had evidence for a new three-dimensional form of DNA." When Watson "asked what the pattern [of this new form] was like, [Wilkins] went into the adjacent room to pick up an [X-ray diffraction] print [or photograph] of [this] new form [called the 'B' form]" and showed it to Watson. This was done without Franklin's permission. It turns out that this X-ray photo was critical and "gave several...vital helical parameters."
(4) WATSON'S HONESTY. In all of this book, Franklin is portrayed as an unattractive, unapproachable, and angry person whose scientific work is questionable. However, in the book's epilogue Watson devotes the last two paragraphs to her and her achievements. He admits that "my initial impressions of her, both scientific and personal...were often wrong" and that she was a person of "personal honesty and generosity" as well as of "intelligence."
Two good features of this book are that it has photographs (a total of 19) and diagrams (a total of 11) throughout. My favorite photo is the one captioned "X-ray diffraction photograph of DNA, B form" taken by Franklin in late 1952. My favorite diagram is captioned "Schematic illustration of the double helix."
This book was written for a general audience so they could experience the thrill of this revolutionary discovery. Thus, I was surprised that it had no chapter table of contents (but the photos and diagrams each have one), no chapter headings, and no index. I feel these would have made the book more user friendly.
Also, I feel what was needed was a science glossary and name index/page. The former is needed because the reader encounters many scientific terms (especially those related to DNA) and thus a glossary would make the science more accessible to the general reader. The latter is needed because Watson encounters many people and a name index/page would have helped the reader keep track of these names. Besides Watson talked with other scientists to clarify ideas, and in a way they indirectly contributed to the discovery. Thus, a name index/page would have acknowledged their indirect contribution.
Finally, in the epilogue Watson states, "All of [the major] people [in this book], should they desire, can indicate events and details they remember differently." Thus, I recommend these books:
(1) "Linus Pauling: Scientist and Peacemaker" (2001). In this book, refer to the science article entitled "The Triple Helix" which describes the race to discover DNA's structure. Note Pauling's observations throughout the article.
(2) "Rosalind Franklin and DNA" (first published in 1975) by Anne Sayre. This book clears up Watson's misconceptions about Franklin who died in 1958.
(3) "The Third Man of the Double Helix" (2003) by Maurice Wilkins. Wilkins finally speaks out on what really happened from his perspective.
In conclusion, Dr. James Watson tells us honestly his version of how the structure of DNA was discovered. He effectively conveys the struggle to find the right answer and the thrill of discovery. Don't deny yourself from reading this exciting book but be sure to read the recommended books to get the full story.
*** 1/2
+++++
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9 of 9 people found the following review helpful:
5.0 out of 5 stars
A Geneticist Looks at the Double Helix, January 13, 2001
_________________________________________________________________When "The Double Helix" came out in 1968, as a geneticist I naturally read it. And it has stuck far more firmly for me than any of the many other books I've read over the years about genetics. Why do I remember this book so well? I've wondered. The answer is right in the first sentence of "The Double Helix" that reads: "I have never seen Francis Crick in a modest mood." In his account of how the structure of DNA was discovered, Jim Watson doesn't try to tell the story from a disinterested point of view. This is my version, he says, and I'm not going to touch it up to cover the warts and other blemishes. Yes, for instance, Watson and Crick were patently and terribly unfair and unjust toward Rosalind Franklin but Jim doesn't deny it. He makes it plenty clear. Most writing in and about science is well varnished. But varnish gives a gloss and it's not easy to hold onto. Jim Watson forgot the varnish, on purpose. Watson's brashness (and Crick's conceit) season this narrative in a memorable way, a way I can't easily forget, even if I wanted to. This is first-rate personal science writing. Five stars, for sure, or more. It's about one of the most important discoveries in the history of science. I hope you'll enjoy (and remember) "The Double Helix" too.
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18 of 21 people found the following review helpful:
5.0 out of 5 stars
It does not distort the facts; pay attention when you read!, May 13, 2000
I read this book for the first time when i took undergraduate biochemistry in college. I could not put it down. Now, ten years later, i found it at a second-hand store and re-read it, and once again read it in two sittings. This book reads like a thriller. You definitively catch a sense of the urgency of their research. I was flipping pages nervously, like i didn't know Watson and Crick were the ones who won the race.In the edition i have, Watson is very thankful about the contributions that Rosalind Franklin made to their discovery. He is crystal clear about how she was the one convinced that the backbone was on the outside, and had not he followed her advice, it would have taken him even longer to figure out the structure, and who knows?, Pauling might have gotten there first. In the epilogue, Watson is all praise about Rosalind, acknowledges how his opinions about her were often wrong, how excellent the quality of her work was, and ponders about the obstacles that she encountered in her career in science for being a woman. I wonder if these comments were missing in other people's books, because according to their critiques, one comes out with the idea that Watson and the male-dominated scientific establishment gave Rosalind the cancer that killed her. This is an excellent, honest account of an event that took place when the author was 25 years old. I could not believe my eyes when i read that sentence. Twenty-five, worrying about girls and tennis and the structure of the most important molecule in the universe. These facts might count for something. This is a must-read book, for everybody, whether you understand science or not.
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