A Primer of Genome Science (Paperback)

~ (Author), Spencer V. Muse (Author) "Genome science is the study of the structure, content, and evolution of genomes..." (more)
Key Phrases: Acids Res, Natl Acad, Genome Res (more...)

Editorial Reviews

Review

"...remarkably comprehensive & organized given its length, covering most model organisms & many new & emerging techniques " -- Mark Lubkowitz, BioScience

Product Description

Genome science as a discipline is less than five years old, but has already spawned a revolution in the way in which genetics is taught in universities, approached by academic researchers, and applied by pharmaceutical and agricultural research companies. While over a dozen new journals devoted to genomics have appeared in the last few years, no introductory textbook that covers the range of disciplines incorporated into genome science has materialized, until now. A Primer of Genome Science bridges the gap between standard genetics textbooks and highly specialized, technical, and advanced treatments of the subdisciplines. It provides an affordable and up-to-date introduction to the field that is suited to advanced undergraduate or early graduate courses. Bioinformatic principles and experimental strategies are explained side-by-side with the experimental methods, establishing a framework that allows teachers to explore topics and the literature at their own pace.

The Primer is organized into six chapters. Each chapter includes: exercises that can be worked by students using the internet and freely available software for analysis of genomic data; discussion questions; a summary; and suggestions for further reading. An Appendix includes a glossary of terms, with a brief review of key genetic concepts.

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Product Details

• Paperback: 347 pages
• Publisher: Sinauer Associates; 1st edition (December 3, 2001)
• Language: English
• ISBN-10: 0878932348
• ISBN-13: 978-0878932344
• Product Dimensions: 9.3 x 6.9 x 0.7 inches
• Shipping Weight: 1.6 pounds
• Average Customer Review: 4.2 out of 5 stars  See all reviews (4 customer reviews)
• Amazon.com Sales Rank: #1,338,378 in Books (See Bestsellers in Books)

Customer Reviews

Most Helpful Customer Reviews

13 of 14 people found the following review helpful:

4.0 out of 5 stars Excellent overview of Functional and Structural Genomics, March 19, 2002

By A Customer

This somewhat understated book may be overlooked based on its title, and yet it represents the best book currently in print to provide a solid overview of the science and issues in genome science, functional and structural genomics, and the subdiscipline proteomics. Chapter 1 describes current progress with mapping genomes, including the human genome and other genomes in plants and animals. Chapter 2 describes sequencing approaches and gene identification. Chapter 3 deals with gene expression and technologies. Chapter 4 focuses on proteomics including brief introductions to 2D-PAGE and mass spectrometry. This chapter also briefly introduces the reader to structural genomics, or the prediction of protein structure based on sequence through threading and modeling. After a chapter on single nucletide polymorphisms and genotyping the book concludes with a chapter on integrating genome studies including the use of in silico approaches.
Although scant in detail in parts, a major strength of the book is the wide coverage given to science of genomics and its offshoots. Overall an excellent course text for undergraduate or early postgraduate students or others interested in these emerging disciplines. I am not aware of any competing texts which such coverage and certainly not at the price of this one.

2 of 3 people found the following review helpful:

5.0 out of 5 stars The future may view this text as a foundation for GS, May 15, 2003

By	RG (Durham, NC USA) - See all my reviews

Every technician and/or PI should own a copy of this text for their lab. With the logical diagrams and full explanation of the text, this book is really condensed and assumes some knowledge of molecular biology. This book does not assume knowledge of genomics, but rather serves as a manual.

5.0 out of 5 stars Up to Date and Very Well Done, August 10, 2005

By	John Matlock "Gunny" (Winnemucca, NV) - See all my reviews (REAL NAME)

This review is from: A Primer of Genome Science, 2nd Edition (Paperback)

With the basic science being so new and changing so rapidly, this second edition is timely and welcome. Virtually every chapter has been re-written to bring it up to date. The result is a text suitable for use in upper under grad or beginning grad level course in functional genomics or bioinformatics. The six chapter headings are:

Genome Projects: Organization and Objectives
Genome Sequencing and Annotation
SNPs and Variation
Gene Expression and the Transcriptome
Proteomics and Functional Genomics
Integrative Genomics.

The book is well written and profusely illustrated with color drawings and photographs. The book is closely allied with the web in form of accessable databases and the like which may keep it from going out of date so fast.

With most text books being so expensive, this book is a definite sleeper in the field.