Guide to Biomolecular Simulations (Focus on Structural Biology) (Hardcover)

by Oren M. Becker (Author), Martin Karplus (Author)

Editorial Reviews

Review
From the reviews:

"The Guide to Biomolecular Simulations intends to provide students and nonexperts with an introductory, self-contained course about the application of molecular dynamics and related methodologies. The book emerged from a biophysics course held at Harvard in the 1990s and is therefore suited for standalone self-study as well as for classroom use a ] . And finally, a reader who successfully worked through the book obtained significant experience in using CHARMM, one of the most widely used molecular dynamics packages in biomolecular simulations." (Anselm H. C. Horn, Journal of Chemical Information and Modeling, Vol. 46 (6), 2006)

Product Description
Molecular dynamics simulations have become instrumental in replacing our view of proteins as relatively rigid structures with the realization that they were dynamic systems, whose internal motions play a functional role. Over the years, such simulations have become a central part of biophysics. Applications of molecular dynamics in biophysics range over many areas. They are used in the structure determination of macromolecules with x-ray and NMR data, the modelling of unknown structures from their sequence, the study of enzyme mechanisms, the estimation of ligand-binding free energies, the evaluation of the role of conformational change in protein function, and drug design for targets of known structures. The widespread application of molecular dynamics and related methodologies suggests that it would be useful to have available an introductory self-contained course by which students with a relatively limited background in chemistry, biology and computer literacy, can learn the fundamentals of the field. This Guide to Biomolecular Simulations tries to fill this need. The Guide consists of six chapters which provide the fundamentals of the field and six chapters which introduce the reader to more specialized but important applications of the methodology.

Product Details

• Hardcover: 220 pages
• Publisher: Springer; 1 edition (December 22, 2005)
• Language: English
• ISBN-10: 1402035861
• ISBN-13: 978-1402035869
• Product Dimensions: 9.5 x 6.4 x 0.7 inches
• Shipping Weight: 1.1 pounds (View shipping rates and policies)
• Average Customer Review: 3.0 out of 5 stars See all reviews (1 customer review)
• Amazon.com Sales Rank: #1,792,213 in Books (See Bestsellers in Books)

Customer Reviews

Most Helpful Customer Reviews

2 of 2 people found the following review helpful:

3.0 out of 5 stars The book IS NOW shipped with the required CD, June 3, 2006

By	Ibdeno - See all my reviews

This is not truly a review (I had to give a rate because it is compulsory when submitting a review to Amazon), since for following this book one would require all the materials needed to perform the practical "labs" in what it is divided. Particularly, the book should be shipped along with a CD including files and data necessary for the "labs". The book mentions that a CD is distributed with it, but in fact this CD was not sent. I contacted the publishers but had no answer. One of the authors very swiftly and kindly answered to my request and he promptly told the publishers about the problem. Apparently the CD should be shipped soon, although I have not heard yet from the publishers.
This comment is just to tell people to wait and buy the book only when it is announced to have a companion CD.