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Pharmacokinetic Analysis: A Practical Approach
 
 
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Pharmacokinetic Analysis: A Practical Approach (Hardcover)

~ I-Der Lee (Author), Gordon Amidon (Author) "This text presents a unifying view of pharmacokinetics, which is called the Time Constant Approach..." (more)
Key Phrases: time constant plot, metabolite concentration curve, mean plasma concentration profiles, Time Constant Approach, Value Equation, Estimated Time Constants of Model (more...)
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Editorial Reviews

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This insightful work provides a useful introduction to the very large and important field of pharmacokinetics. The authors have selected the Time Constant Approach as a unifying view within which to present important application areas. In addition to providing consistency, their approach provides the novice with an intuitive time view that is meaningful from the outset. This approach allows one to get a "feel" for the data and to relate it to other data in a direct and accessible manner. The Time Constant Approach provides a synthesis of the noncompartmental and compartmental methods, with the advantages of both. It starts by defining a physiologically meaningful model based on the pharmacokinetic processes involved. The Time Constant Approach recognizes pharmacokinetics as a number of processes that move drugs between physiological compartments, each process occurring at its own characteristic length of time, to correlate descriptive pharmacokinetic events with time constants of pharmacokinetic processes. While analogous to the three most common testing approaches for pharmacokinetics (the noncompartmental, compartmental and statistical moment approaches) the Time Constant Approach possesses many advantages.

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Peter I. D. Lee
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Inside This Book (learn more)
First Sentence:
This text presents a unifying view of pharmacokinetics, which is called the Time Constant Approach. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
time constant plot, metabolite concentration curve, mean plasma concentration profiles, simulated plasma concentration profiles, time constant analysis, key time constants, plasma drug concentration profiles, estimated pharmacokinetic parameters, mean output time, total clearance time, estimated time constants, mean concentration curves, time constant view, pharmacokinetic time constants, mean concentration profiles, descriptive pharmacokinetic parameters, interaction affecting protein binding, first decay time, concentration curve decreases, creatinine clearance time, metabolic elimination time, tissue penetration study, partial area under the curve, concentration curve increases, mean input time
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Time Constant Approach, Value Equation, Estimated Time Constants of Model, Model Value, Pharmaceutical Research, Journal of Pharmaceutical Sciences, Mean Elimination, International Journal of Clinical Pharmacology, Blackwell Science Ltd, Mean Initial, Absorption Renal, Mean Mean Decay, Special Pharmacokinetic Considerations, Influence of Dosage, Journal of Antimicrobial Chemotherapy, Other Diseases, Decay Mean Renal Hepatic, First Second Absorption, Marcel Dekker, Mean Mean Total Norm, Model Model Model Model Parameter, Parameter Value, The Estimated Pharmacokinetic Parameters of Model, The Journal of Nuclear Medicine, Time Constant Analysis Using Model
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