Process Scale Bioseparations for the Biopharmaceutical Industry (Biotechnology and Bioprocessing Series) (Hardcover)

~ Abhinav A. Shukla (Editor), Mark R. Etzel (Editor), Shishir Gadam (Editor)
Key Phrases: leached protein, pass centrate, refold buffer, New York, Journal of Chromatography, Biotechnol Bioeng (more...)

Editorial Reviews

Review

…this book is suitable for the growing number of scientific staff involved in biopharmaceutical and biotechnological industries, as well as for graduate students and senior level undergraduates who are preparing for a career in bioprocessing.
-Chembiotech Laboratories

…this book is suitable for the growing number of scientific staff involved in biopharmaceutical and biotechnological industries, as well as for graduate students and senior level undergraduates who are preparing for a career in bioprocessing.
-Chembiotech Laboratories

Product Description

The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules.

Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends.

Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development.

Product Details

• Hardcover: 575 pages
• Publisher: CRC; 1 edition (July 7, 2006)
• Language: English
• ISBN-10: 1574445170
• ISBN-13: 978-1574445176
• Product Dimensions: 8.9 x 6.3 x 1.5 inches
• Shipping Weight: 1.9 pounds (View shipping rates and policies)
• Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
• Amazon.com Sales Rank: #455,864 in Books (See Bestsellers in Books)

Customer Reviews

Most Helpful Customer Reviews

5.0 out of 5 stars Great Industrial Supplement to Scopes, March 30, 2009

By	TocaLaGuitarra (Vista, CA United States) - See all my reviews

Amazon Verified Purchase

This is a nice book for those in the industry or students wanting to see how the theories presented in Scopes' "Protein Purification" (or similar) are implemented at larger scales. The book is organized topically so you can jump from one to the other out of order if you like. The chapters on "Modes of Preparatory Chromatography" (esp. the treatment of HIC), "Screening of Chromatographic Stationary Phases", and "Protein A Affinity Chromatography..." and "Polishing Methods..." are particularly well executed. You don't get the sense that this book is just a marketing channel for some company and their products, which is more than I can say for some of the other books out there on the subject. Good buy.